Acetaminophen

Mpox, primarily transmitted through close skin contact, typically causes a self-resolving illness but can be severe in immunocompromised individuals. First-line therapy is supportive care; advanced therapeutics are available for severe cases. Vaccination with the 2-dose Modified Vaccinia Ankara-Bavarian Nordic vaccine is recommended for high-risk populations, with efficacy rates of 66% to 86%.

18 state attorneys general, including Connecticut's William Tong, demand a federal judge remove FDA restrictions on mifepristone, arguing the drug is safer than Tylenol and has unnecessary restrictions.

Washington AG Bob Ferguson leads coalition of 18 AGs suing FDA over mifepristone restrictions, arguing they are unlawful and politically motivated. A federal judge granted a preliminary injunction in April 2023, preventing the FDA from reducing mifepristone's availability in Washington and 16 other states. The lawsuit claims the FDA's restrictions on mifepristone are unnecessary and harmful, reducing access to safe reproductive care.

Attorney General William Tong and 17 other AGs filed a motion urging a federal judge to strike FDA restrictions on mifepristone, arguing the drug is safer than Tylenol and has decades of safe use data. The motion seeks new regulations based on science and safety.

Researchers developed an in vitro human liver model that mimics circadian rhythms, identifying cyclical gene expression affecting drug metabolism and immune responses. This model, sustained for 10 weeks, revealed that drug-metabolizing enzyme CYP3A4 activity varies by time of day, impacting drug toxicity. The system also showed that liver cells are more susceptible to infections like malaria when immune response genes are downregulated, emphasizing the importance of circadian rhythms in liver function and drug development.

Elite Pharmaceuticals introduces generic acetaminophen and codeine phosphate tablets (300mg/15mg, 300mg/30mg, 300mg/60mg) for mild to moderate pain, marketed under Elite Laboratories label. The market value was $47 million as of May 2024.

A study by Fakayode et al. combines Raman and UV-visible spectroscopy with PCA and PLS regression to quantify active ingredients in OTCM syrups, offering a rapid, cost-effective method for quality control, crucial for detecting counterfeit drugs.

A single-center, randomized, evaluator-blinded pilot study assesses the therapeutic efficacy of Fu’s subcutaneous needling (FSN) versus electroacupuncture (EA) in knee osteoarthritis (OA) patients, focusing on muscle stiffness measured by shear wave elastography (SWE). The study aims to alleviate pain, enhance joint function, and improve quality of life, comparing FSN and EA for immediate pain relief and functional recovery. It addresses the limitations of existing diagnostic methods for muscular health and explores the potential of SWE for assessing muscle elasticity in OA. The trial, registered with the Chinese Clinical Trial Registry, involves 60 patients randomly assigned to FSN or EA groups, with four-week interventions and a one-month follow-up. The study highlights the importance of muscular function in OA pathogenesis and management, aiming to contribute to evidence-based practices and future research directions.

Elite Pharmaceuticals launches generic Tylenol with Codeine tablets in 300mg/15mg, 300mg/30mg, and 300mg/60mg strengths for mild to moderate pain, entering a $47 million market.