Duloxetine

Generic Name
Duloxetine
Brand Names
Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
Drug Type
Small Molecule
Chemical Formula
C18H19NOS
CAS Number
116539-59-4
Unique Ingredient Identifier
O5TNM5N07U
Background

Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...

Indication

Indicated for:

1) Management of Major Depressive Disorder.

2) Management of Generalized Anxiety Disorder.

3) Management of diabetic peripheral neuropathy.

4) Management of fibromyalgia.

5) Management of chronic musculoskeletal pain.

6) Management of osteoarthritis of the knee in adults.

7) Management of chronic lower back pain in adults.
...

Associated Conditions
Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
Associated Therapies
-
Clinical Trials
Related News

A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder

First Posted Date
2020-07-17
Last Posted Date
2023-12-22
Lead Sponsor
Biogen
Target Recruit Count
440
Registration Number
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Locations
🇺🇸

Sage Investigational Site, Bellevue, Washington, United States

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea

First Posted Date
2020-06-24
Last Posted Date
2024-12-09
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Target Recruit Count
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Registration Number
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Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy, Psychological Distress, Sexual Function, Urethral and Bladder Wall Structure and Blood Flow in Women With Stress Urinary Incontinence: a Randomized Controlled Study

First Posted Date
2020-06-02
Last Posted Date
2022-08-17
Lead Sponsor
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Registration Number
NCT04412876
Locations
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Department of Obstetrics and Gynecology, Far-Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan

Pain Response Evaluation of a Combined Intervention to Cope Effectively

First Posted Date
2020-05-20
Last Posted Date
2024-12-20
Lead Sponsor
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Target Recruit Count
345
Registration Number
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Locations
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Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion

Phase 4
Withdrawn
Conditions
Major Depressive Disorder
Interventions
Drug: Duloxetine
Drug: Bupropion
First Posted Date
2020-05-14
Last Posted Date
2020-10-19
Lead Sponsor
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Registration Number
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Intestinal Flora and Major Depressive Disorders

First Posted Date
2020-04-15
Last Posted Date
2020-04-17
Lead Sponsor
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Target Recruit Count
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Registration Number
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Locations
🇨🇳

Beijing Chao-Yang Hospital, Beijing, Beijing, China

Duloxetine for PHN

Not Applicable
Completed
Conditions
Postherpetic Neuralgia
Interventions
Drug: Duloxetine
First Posted Date
2020-03-18
Last Posted Date
2024-01-09
Lead Sponsor
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Target Recruit Count
750
Registration Number
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Beijing Tiantan Hospital, Beijing, Beijing, China

Efficacy of Perioperative Duloxetine as a Part of Multimodal Analgesia in Laparoscopic Colorectal Cancer Surgery

First Posted Date
2020-03-04
Last Posted Date
2020-03-04
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Registration Number
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Efficacy of Pregabalin and Duloxetine in Patients With PDPN: the Effect of Pain on Cognitive Function, Sleep and Quality of Life

First Posted Date
2020-01-29
Last Posted Date
2022-04-07
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KRKA
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254
Registration Number
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Locations
🇸🇮

Zdravstveni dom Koper, Koper, Slovenia

🇭🇷

Opća bolnica Karlovac, Karlovac, Croatia

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Klinička bolnica Sveti Duh, Zagreb, Croatia

and more 10 locations

Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)

First Posted Date
2020-01-29
Last Posted Date
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Lead Sponsor
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Target Recruit Count
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Registration Number
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Locations
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University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio, United States

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