Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke

Phase 4

Recruiting

Conditions: Acute Ischemic Stroke

Interventions: Drug: Midazolam
Drug: Dexmedetomidine

First Posted Date: 2023-11-18

Last Posted Date: 2024-11-27

Lead Sponsor: Jinling Hospital, China

Target Recruit Count: 810

Registration Number: NCT06139692

Locations: 🇨🇳
Jinling Hospital, Medical School of Nanjing University, Nanjing, None Selected, China
🇨🇳
The General Hospital of Western Theater Command PLA, Chengdu, China

Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

Not Applicable

Not yet recruiting

Conditions: Rhinoplasty Surgery

Interventions: Drug: Dexmedetomidine
Drug: Remifentanil

First Posted Date: 2023-11-18

Last Posted Date: 2023-11-18

Lead Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Target Recruit Count: 72

Registration Number: NCT06138574

Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief

Not Applicable

Recruiting

Conditions: Carpal Tunnel
Dexmedetomidine
Ozone
Dexamethasone

Interventions: Drug: Ozone
Drug: Dexmedetomidine
Drug: Dexamethasone

First Posted Date: 2023-11-15

Last Posted Date: 2024-11-19

Lead Sponsor: Tanta University

Target Recruit Count: 135

Registration Number: NCT06133712

Locations: 🇪🇬
Faculty of Medicine, Tanta, El Gharbia, Egypt

Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery

Not Applicable

Recruiting

Conditions: Dexmedetomidine
Chronic Obstructive Pulmonary Disease
Aminophylline
Obese
Lung Mechanics
Laparoscopic Bariatric Surgery

Interventions: Drug: Aminophylline-Dexmedetomidine
Drug: Dexmedetomidine

First Posted Date: 2023-11-09

Last Posted Date: 2023-11-14

Lead Sponsor: Tanta University

Target Recruit Count: 60

Registration Number: NCT06125665

Locations: 🇪🇬
Tanta University, Tanta, El-Gharbia, Egypt

Dexmedetomidine Effect on Delirium of Elderly Patients

Phase 4

Not yet recruiting

Conditions: Delirium in Old Age

Interventions: Drug: Dexmedetomidine

First Posted Date: 2023-11-01

Last Posted Date: 2023-11-01

Lead Sponsor: Assiut University

Target Recruit Count: 86

Registration Number: NCT06111300

Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Dental Treatment

Completed

Conditions: Postoperative Pain
Anxiety
Nausea

Interventions: Drug: Dexmedetomidine
Drug: Fentanyl

First Posted Date: 2023-10-24

Last Posted Date: 2024-02-29

Lead Sponsor: Medipol University

Target Recruit Count: 80

Registration Number: NCT06097169

Locations: 🇹🇷
Istanbul Medipol University, Istanbul, Turkey

Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress Marker

Not Applicable

Completed

Conditions: Propofol
Salivary Alpha Amylase
Dexmedetomidine
Mechanical Ventilation
Stress

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2023-10-24

Last Posted Date: 2024-05-14

Lead Sponsor: Tanta University

Target Recruit Count: 40

Registration Number: NCT06098209

Locations: 🇪🇬
Tanta University, Tanta, El-Gharbia, Egypt

Hypotensive Anesthesia for Orthognathic Surgery

Phase 4

Not yet recruiting

Conditions: Hypotensive Anesthesia
Orthognathic Surgery

Interventions: Drug: Dexmedetomidine
Drug: Nicardipine
Drug: Labetalol

First Posted Date: 2023-10-23

Last Posted Date: 2024-12-05

Lead Sponsor: Boston Medical Center

Target Recruit Count: 90

Registration Number: NCT06093893

Locations: 🇺🇸
Boston Medical Center, Boston, Massachusetts, United States

Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder

Phase 4

Recruiting

Conditions: Schizo Affective Disorder
Schizophrenia Agitation
Dexmedetomidine
Bipolar Disorder

Interventions: Drug: Lorazepam 2 MG/ML
Drug: Dexmedetomidine

First Posted Date: 2023-10-23

Last Posted Date: 2023-10-23

Lead Sponsor: Temple University

Target Recruit Count: 32

Registration Number: NCT06093451

Locations: 🇺🇸
Temple University Episcopal Hospital, Philadelphia, Pennsylvania, United States

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic Scoliosis Surgery

Phase 4

Recruiting

Conditions: Scoliosis Idiopathic
Scoliosis; Adolescence

Interventions: Drug: 0.9% sodium chloride
Drug: Dexamethasone
Drug: Dexmedetomidine

First Posted Date: 2023-10-17

Last Posted Date: 2024-01-23

Lead Sponsor: Poznan University of Medical Sciences

Target Recruit Count: 90

Registration Number: NCT06086431

Locations: 🇵🇱
Department of Spine Diseases and Pediatric Orthopedics, University of Medical Sciences, Poznań, Poland, Poznań, Wielkopolska, Poland

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