Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film...

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine in Reducing Postoperative Delirium Among Cardiac Surgery Patients with Preoperative Sleep Disorders

Phase 2

Not yet recruiting

Conditions: Postoperative Delirium
Preoperative Sleep Disorder

Interventions: Drug: Dexmedetomidine

First Posted Date: 2024-10-01

Last Posted Date: 2024-11-20

Lead Sponsor: Xijing Hospital

Target Recruit Count: 654

Registration Number: NCT06619912

Effects of Dexmedetomidine on Agitation in Critically Ill TBI Patients

Phase 2

Not yet recruiting

Conditions: Traumatic Brain Injury
Agitation,Psychomotor

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2024-10-01

Last Posted Date: 2024-10-01

Lead Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

Target Recruit Count: 72

Registration Number: NCT06620393

Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries

Not Applicable

Completed

Conditions: Surgical Field Quality Improvement in Spine Surgeries

Interventions: Other: Saline (NaCl 0,9 %) (placebo)
Drug: Tranexamic acid
Drug: Dexmedetomidine

First Posted Date: 2024-09-09

Last Posted Date: 2024-09-09

Lead Sponsor: Zagazig University

Target Recruit Count: 78

Registration Number: NCT06587620

Locations: 🇪🇬
Faculty of medicine, zagazig university, Zagazig, Elsharqya, Egypt
🇪🇬
Zagazig University, Zagazig, Egypt

Comparison of the Effects of Dexmedetomidine and Lidocaine on Blood Pressure and Heart Rate Response

Not Applicable

Completed

Conditions: General Anesthesia

Interventions: Drug: Lidocain
Drug: Dexmedetomidine

First Posted Date: 2024-08-27

Last Posted Date: 2024-08-27

Lead Sponsor: Universitas Padjadjaran

Target Recruit Count: 42

Registration Number: NCT06573957

Locations: 🇮🇩
RSUP Dr. Hasan Sadikin, Bandung, West Java, Indonesia

The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

Phase 4

Recruiting

Conditions: Sepsis
Septic Shock
Acute Kidney Injury

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2024-08-26

Last Posted Date: 2024-10-09

Lead Sponsor: Cairo University

Target Recruit Count: 128

Registration Number: NCT06570187

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Dexmedtomodine Effect on Agitated Psychotic Patients Suffer COPD

Active, not recruiting

Conditions: Response of Agitated Patients to Dexmedetomidine

Interventions: Drug: Dexmedetomidine
Device: BIPAP

First Posted Date: 2024-08-22

Last Posted Date: 2024-08-22

Lead Sponsor: Tanta University

Target Recruit Count: 70

Registration Number: NCT06567587

Locations: 🇪🇬
Tanta, Tanta, State/Province:*, Egypt

Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium

Phase 4

Not yet recruiting

Conditions: Nasal Administration
Esketamine
General Anesthesia
Dexmedetomidine
Older Patients
Emergence Delirium

Interventions: Drug: Normal saline
Drug: Dexmedetomidine
Drug: Esketamine

First Posted Date: 2024-08-22

Last Posted Date: 2024-08-22

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 340

Registration Number: NCT06566469

Locations: 🇨🇳
Peking University First Hospital, Beijing, Beijing, China

Comparison Between Effect of Vitamin D Versus Dexmedetomidine in Patients with Head Trauma Using Interleukin 6

Completed

Conditions: Traumatic Brain Injury

Interventions: Drug: Dexmedetomidine
Drug: Vitamin D3

First Posted Date: 2024-08-21

Last Posted Date: 2024-11-04

Lead Sponsor: Minia University

Target Recruit Count: 60

Registration Number: NCT06565338

Locations: 🇪🇬
Asmaa, Minya, Egypt

Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia

Not Applicable

Completed

Conditions: Labor Analgesia
Labor Pain

Interventions: Drug: Dexmedetomidine
Drug: Bupivacain

First Posted Date: 2024-08-13

Last Posted Date: 2024-08-13

Lead Sponsor: Services Institute of Medical Sciences, Pakistan

Target Recruit Count: 165

Registration Number: NCT06550414

Locations: 🇵🇰
Hameed Lateef Hospital, Lahore, Punjab, Pakistan

Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries

Phase 1

Recruiting

Conditions: Emergence Delirium

Interventions: Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2024-08-09

Last Posted Date: 2024-08-20

Lead Sponsor: Cairo University

Target Recruit Count: 46

Registration Number: NCT06545890

Locations: 🇪🇬
Abu Elresh Hospitals ( Cairo university ), Cairo, Egypt
🇪🇬
Abu ElResh hospital, Cairo, Egypt

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