Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film...

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexamethasone Versus Demedetomidine Addition for Adductor Canal Block

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Dexmedetomidine
Drug: Dexamethasone

First Posted Date: 2024-07-30

Last Posted Date: 2024-07-30

Lead Sponsor: Assiut University

Target Recruit Count: 90

Registration Number: NCT06527976

Locations: 🇪🇬
Assiut university, Assiut, Egypt

Nebulized Dexmedetomidine Versus Oral Sumatriptan in Treatment of Post Dural Puncture Headache in Cesarean Section

Not Applicable

Recruiting

Conditions: Post-Dural Puncture Headache

Interventions: Drug: Sumatriptan 25 mg
Drug: Precedex

First Posted Date: 2024-07-23

Last Posted Date: 2024-07-23

Lead Sponsor: Fayoum University Hospital

Target Recruit Count: 48

Registration Number: NCT06514040

Locations: 🇪🇬
Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt

Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery

Not Applicable

Completed

Conditions: Thoracic Surgery
One-Lung Ventilation

Interventions: Drug: Normal saline
Drug: Dexmedetomidine

First Posted Date: 2024-07-17

Last Posted Date: 2024-07-23

Lead Sponsor: Damascus University

Target Recruit Count: 78

Registration Number: NCT06505772

Locations: 🇸🇾
University Children's Hospital, Damascus, Syrian Arab Republic

A Comparative Study of Intrathecal Dexmedetomidine and Fentanyl as Additives to Bupivacaine in Pott's Fracture

Not Applicable

Not yet recruiting

Conditions: Post Operative Pain

Interventions: Drug: Bupivacaine Hydrochloride
Drug: Fentanyl
Drug: Dexmedetomidine

First Posted Date: 2024-07-16

Last Posted Date: 2024-07-16

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT06502262

Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal Surgeries

Early Phase 1

Completed

Conditions: Vitreoretinal Surgeries
Local Anesthesia

Interventions: Drug: Neostigmine
Drug: Saline
Drug: Dexmedetomidine

First Posted Date: 2024-07-15

Last Posted Date: 2024-07-15

Lead Sponsor: Ain Shams University

Target Recruit Count: 81

Registration Number: NCT06501352

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

Intraoperative Subanesthetic Ketamine Versus Dexmedetomidine Infusion for Prevention of Post-traumatic Stress Disorder After Traumatic Brain Surgeries

Not Applicable

Conditions: Subanesthetic Ketamine Dexmedetomidin

Interventions: Drug: ketamine
Drug: dexmedetomidine

First Posted Date: 2024-07-12

Last Posted Date: 2024-08-19

Lead Sponsor: Zagazig University

Target Recruit Count: 52

Registration Number: NCT06498700

Locations: 🇪🇬
Faculty of Medicine,Zagazig University, Zagazig, El Sharkia, Egypt

Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients

Phase 1

Recruiting

Conditions: Haemodynamic Rebound

Interventions: Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2024-07-08

Last Posted Date: 2024-11-27

Lead Sponsor: New Valley University

Target Recruit Count: 2

Registration Number: NCT06490731

Locations: 🇪🇬
asyut University, Asyut, Egypt

Dexmedetomidine for Analgosedation to Newborn Infants During Neonatal Intensive Care

Withdrawn

Conditions: Hypnotics and Sedatives
Analgesia
Intensive Care, Neonatal

Interventions: Drug: dexmedetomidine

First Posted Date: 2024-07-01

Last Posted Date: 2024-07-01

Lead Sponsor: Region Skane

Registration Number: NCT06482775

Locations: 🇸🇪
Karolinska Universitetssjukhuset, Stockholm, Sweden
🇸🇪
Skane University Hospital, Lund, Sweden

The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study

Phase 4

Recruiting

Conditions: Postoperative Fatigue
Postoperative Sleep Disturbances
Surgical Stress Response

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2024-06-28

Last Posted Date: 2024-06-28

Lead Sponsor: Ziekenhuis Oost-Limburg

Target Recruit Count: 102

Registration Number: NCT06480539

Locations: 🇧🇪
Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium

Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil

Not Applicable

Recruiting

Conditions: Cholecystectomy

Interventions: Drug: Ketalar
Drug: Dexmedetomidine

First Posted Date: 2024-06-25

Last Posted Date: 2024-08-07

Lead Sponsor: Assaf-Harofeh Medical Center

Target Recruit Count: 90

Registration Number: NCT06473896

Locations: 🇮🇱
Shamir (Asaf Harofe) Medical Center, Be'er Ya'aqov, Israel

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