Zinc oxide

Overview

Zinc oxide is an inorganic compound used in a number of manufacturing processes. It can be found in rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most zinc oxide is produced synthetically. It is also widely used to treat a variety of other skin conditions, in products such as baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.

Indication

For adjunctive treatment of diaper dermatitis. Also, it can be used to treat minor skin irritations (eg, cuts, burns, and scrapes, poison ivy). Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light.

Associated Conditions

Acute Wounds
Atopic Dermatitis
Burns first degree
Diaper Rash
Herpes Labialis
Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding
Intertrigo
Pain
Pruritus
Second Degree Burns
Sensitive Skin
Skin Irritation
Skin candida
Sunburn
Wound
Chafing
Damaged skin
Dry, cracked skin
Facial rash
Heat rash
Superficial Wounds
Watery skin lesions

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants	2016/03/23	NCT02716415	Phase 4	Completed	University of the Philippines
CeraVe Cream Compared to Desitin Paste for Treating Diaper Dermatitis in Infants	2014/11/24	NCT02299206	Not Applicable	Terminated	Northwestern University
Vitamin E Prevention of Visible Light Pigmentation	2013/08/22	NCT01927679	Not Applicable	Completed	Innovaderm Research Inc.
Open-Label Pilot Study of the Efficacy and Safety of Vusion Ointment for the Treatment of Intertrigo	2010/05/07	NCT01118910	Early Phase 1	Completed	Image Dermatology P.C.
A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis	2010/02/09	NCT01065714	Phase 4	Completed	Derm Research, PLLC
Topical Amethocaine Gel for Intramuscular Injection in Term Neonates	2005/12/20	NCT00267111	Phase 2	Completed	Mount Sinai Hospital, Canada

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Sun and Honey	Amara Ventures	85432-001	TOPICAL	10 g in 100 g	4/8/2025
PRENATAL PLUS	AvPAK	50268-677	ORAL	25 mg in 1 1	4/12/2022
Diaper Rash	Kroger Co	30142-020	TOPICAL	400 mg in 1 g	3/24/2025
NAKED SUNDAYS CABANA GLOW MINERAL GLOW SERUM DROPS Illuminating 40mL with Pink Algae SPF 50	NAKED SUNDAYS PTY LTD	81104-961	TOPICAL	14.9 g in 100 mL	8/12/2025
Satin Tint	Brent Loftis, D.O., Inc., A California Medical Corporation	85334-208	TOPICAL	160 mg in 1 g	5/20/2025
BabyDiaperCream	Whole Foods Market	42681-0032	TOPICAL	14 g in 100 g	4/29/2025
Velvet NT Moisturizing Mineral Sunscreen	SKIN BOSS L.L.C.	85503-202	TOPICAL	38 mg in 1 g	5/21/2025
Hello Bello Mineral Sunscreen SPF 50	Hello Bello	73418-106	TOPICAL	100 mg in 1 g	5/14/2025
dAlba Vegan Fresh Sun Cushion	ADMTMAX LLC	84662-060	TOPICAL	11.58 mg in 25 g	6/8/2025
DIY Booster SPF 30 Facial Serum Unscented	Andalou naturals	55560-0107	TOPICAL	1 mg in 1 mL	6/9/2025

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
CALAMINE LOTION B.P.	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	2/5/1993
CALAMINE-D LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	7/3/1979
CALAMINE WITH D.P.H CREAM	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	12/10/1983
BACAMINE LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	3/25/1982
CALAMINE LOTION	N/A	EUROPHARM LABORATOIRES COMPANY LIMITED	N/A	N/A	4/16/2005
AICADRYL LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	9/30/1981
CALOX CREAM	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	2/22/1980
CALAMINE LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	12/29/2004
CALABEN LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	6/24/1980
HI-VETIC A OINT	N/A	SATO PHARMACEUTICAL CO.,LTD.	N/A	N/A	5/18/1984

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
HEMADERM HAEMORRHOIDAL ointment tube	50548	Milpharma Pty Ltd	Medicine	A	10/13/1994
Invisible Zinc Sheer Defence Facial Moisturiser SPF50	301141	iNova Pharmaceuticals (Australia) Pty Ltd	Medicine	A	3/21/2018
People4Ocean SPF50 Sunscreen Vegan	324084	LaGaia Pty Ltd	Medicine	A	9/26/2019
Invisible Zinc Sheer Defence Tinted Moisturiser SPF50 Medium	301140	iNova Pharmaceuticals (Australia) Pty Ltd	Medicine	A	3/21/2018
Neutrogena SheerZinc Dry-Touch Sunscreen Lotion	279242	Johnson & Johnson Pacific Pty Ltd	Medicine	A	8/17/2016
Macutec Essentials	326524	Stiltec Pty Ltd	Medicine	A	11/22/2019
BLACKMORES SUPERKIDS MULTI CHEWABLES	289492	Blackmores Ltd	Medicine	A	5/30/2017
Covitol Cream	101190	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	4/30/2004
BLACKMORES MACU-VISION PLUS	317969	Blackmores Ltd	Medicine	A	5/28/2019
M-Power	364701	Surya Ayurveda	Medicine	A	5/6/2021

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
OLAY COMPLETE 30 UVA/UVB 365 DAILY MOISTURIZING LOTION WITH SPF BROAD SPECTRUM SPF 30 SENSITIVE	procter & gamble inc	02461188	Lotion - Topical	6.9 % / W/W	1/1/2018
SELAN +	span-america medical systems inc.	02489643	Cream - Topical	2 % / W/W	N/A
THUNAS PILE SUP	thuna herbal remedies ltd.	00457299	Suppository - Rectal	225 MG / SUP	12/31/1945
SCAR ZONE SCAR CREAM	cca industries, inc.	02246218	Cream - Topical	3.0 %	11/3/2003
ZINC ONT 15%	stanley pharmaceuticals, a division of vita health products inc.	00178969	Ointment - Topical	15 %	12/31/1965
ARTISTRY BALANCING FOUNDATION	amway canada corporation	02331462	Lotion - Topical	2.0 % / W/W	1/1/2010
PT POWDER PT LIQUID 1 PT LIQUID 2	coralite dental products	00070262	Powder For Solution , Liquid - Dental	70 %	1/19/1993
ZINCOFAX ORIGINAL 15%	glaxo wellcome inc.	01997556	Ointment - Topical	15 %	12/31/1993
CALAMINE LOTION USP	lawton's drug stores ltd.	00728640	Suspension - Topical	80 MG / ML	12/31/1987
SUNSCREEN SPF 15	aloe bloc inc.	02257467	Lotion - Topical	2.0 %	12/15/2004

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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