Colchicine

Generic Name: Colchicine

Brand Names: Colcrys, Gloperba, Lodoco, Mitigare

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₅NO_₆

CAS Number: 64-86-8

Unique Ingredient Identifier: SML2Y3J35T

Background: Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...

Indication: Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...

Associated Conditions: Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke

Associated Therapies: -

Clinical Trials

Drug-Drug Interaction Study of Colchicine and Azithromycin

Phase 1

Completed

Conditions: Pharmacokinetics

Interventions: Drug: Azithromycin
Drug: Colchicine

First Posted Date: 2009-09-24

Last Posted Date: 2009-10-28

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00983294

Drug-Drug Interaction Between Colchicine and Ritonavir

Phase 1

Completed

Conditions: Pharmacokinetics

Interventions: Drug: Colchicine
Drug: Ritonavir

First Posted Date: 2009-09-24

Last Posted Date: 2009-10-15

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00983515

Locations: 🇺🇸
PRACS Institute, Ltd. - Cetero Research, East Grand Forks, Minnesota, United States

Drug-Drug Interaction Between Colchicine and Verapamil ER

Phase 1

Completed

Conditions: Pharmacokinetics

Interventions: Drug: Colchicine
Drug: Verapamil HCl ER

First Posted Date: 2009-09-24

Last Posted Date: 2009-10-15

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00983242

Locations: 🇺🇸
PRACS Institute, Ltd. - Cetero Research, East Grand Forks, Minnesota, United States

Drug-Drug Interaction Study of Colchicine and Clarithromycin

Phase 1

Completed

Conditions: Pharmacokinetics

Interventions: Drug: colchicine
Drug: clarithromycin

First Posted Date: 2009-09-24

Last Posted Date: 2009-10-15

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00984061

Locations: 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States

A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice

Phase 1

Completed

Conditions: Pharmacokinetics

Interventions: Drug: Colchicine
Other: Grapefruit Juice

First Posted Date: 2009-09-24

Last Posted Date: 2011-11-21

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00984009

Locations: 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States

Colchicine Treatment for Chronic Shoulder Pain Related to Calcific Tendonitis

Not Applicable

Conditions: Calcific Tendonitis

Interventions: Drug: Colchicine
Drug: lactose

First Posted Date: 2009-09-23

Last Posted Date: 2010-07-20

Lead Sponsor: Bnai Zion Medical Center

Target Recruit Count: 80

Registration Number: NCT00983177

Locations: 🇮🇱
Bnai Zion Medical Center, Haifa, Israel

Drug-Food Interaction Study of Seville Orange Juice and Colchicine

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Colchicine
Other: Seville Orange Juice

First Posted Date: 2009-08-17

Last Posted Date: 2011-06-08

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00960193

Locations: 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States

Drug-Drug Interaction Study Between Colchicine and Atorvastatin

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Colchicine
Drug: Atorvastatin

First Posted Date: 2009-08-17

Last Posted Date: 2010-03-30

Lead Sponsor: Mutual Pharmaceutical Company, Inc.

Target Recruit Count: 24

Registration Number: NCT00960323

Locations: 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States

Efficacy of Long-term Ribavirin in Non-responders With Chronic Hepatitis C and Advanced Fibrosis

Phase 2

Terminated

Conditions: Chronic Hepatitis C

Interventions: Drug: Colchicine
Drug: Ribavirin

First Posted Date: 2009-02-10

Last Posted Date: 2013-01-31

Lead Sponsor: Hospital Universitario Ramon y Cajal

Target Recruit Count: 50

Registration Number: NCT00840489

Locations: 🇪🇸
Hospital Universitario Ramon y Cajal, Madrid, Spain
🇪🇸
Hospital General Universitario Gregorio Marañón, Madrid, Spain
🇪🇸
Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain

A Study of the Efficacy of Canakinumab in Prevention of Acute Flares in Chronic Gout Patients Initiating Allopurinol Therapy (Core Study) and a Long-term Study of the Efficacy and Safety of Canakinumab in Patients With Gout (Extension Study)

Phase 2

Completed

Conditions: Gout

Interventions: Drug: Canakinumab
Drug: Allopurinol
Drug: Colchicine
Drug: Placebo Matching Canakinumab
Drug: Placebo Matching Colchicine

First Posted Date: 2009-01-09

Last Posted Date: 2018-07-17

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 432

Registration Number: NCT00819585

Locations: 🇺🇸
Talbert Medical Group, Huntington Beach, California, United States
🇺🇸
Health Awareness, Jupiter, Florida, United States
🇺🇸
East-West Medical Research institute, Honolulu, Hawaii, United States

and more 28 locations

Drug Development Updates

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