Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
Efficacy of Colchicine in Preventing Recurrent Stroke in the Patients With Acute Atherothrombotic Ischemic Stroke During Hospitalization
- First Posted Date
- 2023-10-26
- Last Posted Date
- 2023-11-07
- Lead Sponsor
- Mikhail Zykov
- Target Recruit Count
- 200
- Registration Number
- NCT06102720
- Locations
- 🇷🇺
Sochi City Hospital #4, Sochi, Krasnodar Refion, Russian Federation
🇷🇺Research Institute for Complex Issues of Cardiovascular Diseas, Kemerovo, Kemerovo Region, Russian Federation
Anti-inflammatory Therapy for Recurrent In-stent Restenosis
- Conditions
- Interventions
- First Posted Date
- 2023-10-19
- Last Posted Date
- 2023-10-19
- Lead Sponsor
- Fu Wai Hospital, Beijing, China
- Target Recruit Count
- 252
- Registration Number
- NCT06090890
- Locations
- 🇨🇳
Beijing Anzhen Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳Beijing Friendship Hospital, Beijing, Beijing, China
🇨🇳Beijing Luhe Hospital, Beijing, Beijing, China
The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)
- Conditions
- Interventions
- First Posted Date
- 2023-10-12
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Tor Biering-Sørensen
- Target Recruit Count
- 152
- Registration Number
- NCT06081049
- Locations
- 🇩🇰
Center for Translational Cardiology and Pragmatic Randomized Trials, Herlev and Gentofte Hospital, Hellerup, Denmark
Residual Inflammatory Risk-Guided colcHicine in Elderly Trial
- Conditions
- Interventions
- First Posted Date
- 2023-09-06
- Last Posted Date
- 2023-09-06
- Target Recruit Count
- 800
- Registration Number
- NCT06025071
- Locations
- 🇨🇳
Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS & PUMC, Beijing, Beijing, China
Safety and Efficacy of Genakumab for Injection in Patients With Gout Flare
- Conditions
- Interventions
- First Posted Date
- 2023-07-07
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
- Target Recruit Count
- 106
- Registration Number
- NCT05936268
- Locations
- 🇨🇳
Fudan University Affiliated Huashan Hospital, Shanghai, Shanghai, China
The COLchicine and Atrial FIBrillation Trial
- First Posted Date
- 2023-07-03
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Herlev and Gentofte Hospital
- Target Recruit Count
- 500
- Registration Number
- NCT05928728
- Locations
- 🇩🇰
Center for Translational Cardiology and Pragmatic Randomized Trials (CTCPR), Hellerup, Denmark
Colchicine After Electrocardioversion for Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2023-06-06
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 416
- Registration Number
- NCT05890664
- Locations
- 🇨🇭
Cantonal Hospital Baselland (KSBL), Bruderholz, Baselland, Switzerland
🇨🇭University Hospital Basel, Basel, Switzerland
🇨🇭University Hospital Bern, Bern, Switzerland
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
- Conditions
- Interventions
- First Posted Date
- 2023-05-09
- Last Posted Date
- 2024-05-09
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT05850091
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
The Efficacy and Safety of Colchicine Combined With Conventional Therapy in Multiple Myeloma Patients
- First Posted Date
- 2023-04-07
- Last Posted Date
- 2023-04-07
- Lead Sponsor
- Affiliated Hospital of Nantong University
- Target Recruit Count
- 30
- Registration Number
- NCT05802992
- Locations
- 🇨🇳
Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
Hydroxychloroquine in Colchicine-Resistant Glucocorticoid-Dependent Idiopathic Recurrent Pericarditis
- Conditions
- Interventions
- First Posted Date
- 2023-02-21
- Last Posted Date
- 2023-02-22
- Lead Sponsor
- Hippocration General Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT05737680
- Locations
- 🇬🇷
"Hippokration" General Hospital of Athens, Athens, Attiki, Greece
Drug Development Updates
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