Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
The Role of Colchicine in Reducing The Rate of Myocardial Reperfusion Injury
- First Posted Date
- 2023-02-21
- Last Posted Date
- 2023-02-21
- Lead Sponsor
- Indonesia University
- Target Recruit Count
- 80
- Registration Number
- NCT05734612
- Locations
- 🇮🇩
Fakultas Kedokteran Universitas Indonesia, Jakarta Pusat, Jakarta, Indonesia
Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome
- First Posted Date
- 2023-02-13
- Last Posted Date
- 2023-02-13
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT05726019
- Locations
- 🇧🇷
Heart Institute - University of São Paulo, São paulo, Sao Paulo, Brazil
Effect of Colchicine on MMP-9, NOX2, and TGF-β1 in Myocardial Infarct
- First Posted Date
- 2023-02-02
- Last Posted Date
- 2023-04-11
- Lead Sponsor
- RSD dr. Soebandi
- Target Recruit Count
- 148
- Registration Number
- NCT05709509
- Locations
- 🇮🇩
RSD dr Soebandi, Jember, Jawa Timur, Indonesia
Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction
- Conditions
- Interventions
- First Posted Date
- 2022-12-05
- Last Posted Date
- 2023-05-03
- Target Recruit Count
- 40
- Registration Number
- NCT05637398
- Locations
- 🇷🇺
A Shchendrygina, Moscow, Russian Federation
🇷🇺Anastasia Shchendrygina, Moscow, Russian Federation
COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes
- Conditions
- Interventions
- First Posted Date
- 2022-12-01
- Last Posted Date
- 2024-06-06
- Lead Sponsor
- Montreal Heart Institute
- Target Recruit Count
- 10000
- Registration Number
- NCT05633810
- Locations
- 🇨🇦
Montreal Heart Institute, Montréal, Quebec, Canada
The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial
- First Posted Date
- 2022-11-16
- Last Posted Date
- 2024-07-08
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 700
- Registration Number
- NCT05618353
- Locations
- 🇺🇸
VA NY Harbor Healthcare System, New York, NY, New York, New York, United States
🇺🇸Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio, United States
🇺🇸Durham VA Medical Center, Durham, NC, Durham, North Carolina, United States
Effect of Colchicine on Coronary Reperfusion in Patients With Acute Coronary Syndrome
- First Posted Date
- 2022-07-25
- Last Posted Date
- 2023-11-18
- Lead Sponsor
- Pontificia Universidad Catolica de Chile
- Target Recruit Count
- 50
- Registration Number
- NCT05472337
- Locations
- 🇨🇱
Hospital Clínico Pontificia Universidad Catolica de Chile, Santiago, Chile
Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
- First Posted Date
- 2022-06-30
- Last Posted Date
- 2024-06-25
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 8343
- Registration Number
- NCT05439356
- Locations
- 🇨🇳
Baoding Xushui District People's Hospital, Baoding, Hebei, China
🇨🇳Hebei Tang County People Hospital, Baoding, Hebei, China
🇨🇳People's Hospital of Zhongwei, Zhongwei, Ningxia, China
Low-dose Colchicine Inhibit Abdominal Aortic Aneurysm Growth Trial
- Conditions
- Interventions
- First Posted Date
- 2022-05-05
- Last Posted Date
- 2022-05-05
- Lead Sponsor
- Guangdong Provincial People's Hospital
- Target Recruit Count
- 230
- Registration Number
- NCT05361772
Colchicine Effect on Perivascular Inflammation Index on Coronary CTA
- Conditions
- Interventions
- First Posted Date
- 2022-04-26
- Last Posted Date
- 2022-05-09
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT05347316
- Locations
- 🇧🇷
Heart Institute - University of São Paulo, São paulo, Sao Paulo, Brazil
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.