Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
To Evaluate Drug Interactions Between XNW3009, Febuxostat, and Colchicine in Patients With Gout
- First Posted Date
- 2022-04-12
- Last Posted Date
- 2022-05-09
- Lead Sponsor
- The Affiliated Hospital of Qingdao University
- Target Recruit Count
- 20
- Registration Number
- NCT05324423
- Locations
- 🇨🇳
The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
Pilot Trial of Colchicine in Urothelial Cancer and Other Solid Tumors
- First Posted Date
- 2022-03-15
- Last Posted Date
- 2024-02-15
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 45
- Registration Number
- NCT05279690
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
- Conditions
- Interventions
- First Posted Date
- 2022-02-22
- Last Posted Date
- 2024-07-16
- Lead Sponsor
- Azienda USL Toscana Centro
- Target Recruit Count
- 182
- Registration Number
- NCT05250596
- Locations
- 🇮🇹
Gaia Chiara Selvaggia Magnaghi, Pescia, Italy
🇮🇹Marco Comeglio, Pistoia, Italy
🇮🇹Anna Toso, Prato, Italy
Effect of Combined Use of Ivermectin and Colchicine in COVID-19 Patients
- First Posted Date
- 2022-02-18
- Last Posted Date
- 2022-04-07
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 135
- Registration Number
- NCT05246072
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Colchicine Use for Primary Prevention of Coronary Artery Disease
- Conditions
- Interventions
- First Posted Date
- 2022-01-03
- Last Posted Date
- 2022-03-21
- Lead Sponsor
- Qingdao Central Hospital
- Target Recruit Count
- 6792
- Registration Number
- NCT05175274
- Locations
- 🇨🇳
Mengmei Li, Qingdao, Shandong, China
Colchicine and Inflammation in Aortic Stenosis
- Conditions
- Interventions
- First Posted Date
- 2021-12-17
- Last Posted Date
- 2024-05-09
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 150
- Registration Number
- NCT05162742
- Locations
- 🇳🇱
Radboudumc, Nijmegen, The Netherlands, Netherlands
Effect of Inflammasome Inhibitor on hsCRP in Patients After PCI
- Conditions
- Interventions
- First Posted Date
- 2021-11-23
- Last Posted Date
- 2023-02-08
- Lead Sponsor
- Wuhan Union Hospital, China
- Target Recruit Count
- 132
- Registration Number
- NCT05130892
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
🇨🇳Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia.
- First Posted Date
- 2021-11-12
- Last Posted Date
- 2021-12-03
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 230
- Registration Number
- NCT05118737
- Locations
- 🇶🇦
Alaa Rahal, Doha, DA, Qatar
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
- Conditions
- Interventions
- First Posted Date
- 2021-08-24
- Last Posted Date
- 2024-11-06
- Target Recruit Count
- 500
- Registration Number
- NCT05017571
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Mono Antiplatelet and Colchicine Therapy
- Conditions
- Interventions
- First Posted Date
- 2021-07-02
- Last Posted Date
- 2023-01-04
- Lead Sponsor
- Wonkwang University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04949516
- Locations
- 🇰🇷
Wonkwang University Hospital, Iksan, Korea, Republic of
Drug Development Updates
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