Pyridostigmine
- Generic Name
- Pyridostigmine
- Brand Names
- Mestinon, Regonol
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N2O2
- CAS Number
- 155-97-5
- Unique Ingredient Identifier
- 19QM69HH21
- Background
Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 19...
- Indication
Pyridostigmine is indicated for the treatment of myasthenia gravis. When administered intravenously, it is indicated for the reversal or antagonism of the neuromuscular blocking effects of nondepolarizing muscle relaxants.
...
- Associated Conditions
- Congenital Myasthenia (CM), Constipation, Myasthenia Gravis, Neuromuscular Blockade, Post-Poliomyelitis Syndrome, Orthostatic syncope, Soman nerve gas poisoning
- Associated Therapies
- -
LIFT: Life Improvement Trial
- Conditions
- Interventions
- First Posted Date
- 2024-04-16
- Last Posted Date
- 2024-07-25
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 160
- Registration Number
- NCT06366724
Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache
- First Posted Date
- 2023-08-01
- Last Posted Date
- 2024-01-09
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 30
- Registration Number
- NCT05969119
- Locations
- 🇪🇬
Suez General Hospital, Suez, Egypt
Pyridostigmine and Amifampridine for Myasthenia Gravis
- Conditions
- Interventions
- First Posted Date
- 2023-06-26
- Last Posted Date
- 2023-06-26
- Lead Sponsor
- Leiden University Medical Center
- Target Recruit Count
- 24
- Registration Number
- NCT05919407
- Locations
- 🇳🇱
Leiden University Medical Center, Leiden, South-Holland, Netherlands
Pyridostigmine for the Treatment of Constipation in Parkinson Disease
- First Posted Date
- 2022-11-03
- Last Posted Date
- 2023-06-18
- Lead Sponsor
- University of Vermont Medical Center
- Target Recruit Count
- 16
- Registration Number
- NCT05603715
- Locations
- 🇺🇸
University of Vermont Medical Center, Burlington, Vermont, United States
Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-04-19
- Last Posted Date
- 2024-11-12
- Lead Sponsor
- Stefan Holubar MD MS FACS, FASCRS
- Target Recruit Count
- 50
- Registration Number
- NCT05334485
- Locations
- 🇺🇸
Cleveland Clinic Main Campus, Cleveland, Ohio, United States
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
- Conditions
- Interventions
- First Posted Date
- 2020-04-20
- Last Posted Date
- 2024-02-02
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 150
- Registration Number
- NCT04353778
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Pyridostigmine in Severe SARS-CoV-2 Infection
- First Posted Date
- 2020-04-14
- Last Posted Date
- 2020-07-07
- Target Recruit Count
- 436
- Registration Number
- NCT04343963
- Locations
- 🇲🇽
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Tlalpan, Mexico
The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
- Conditions
- Interventions
- First Posted Date
- 2018-09-17
- Last Posted Date
- 2022-11-08
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 45
- Registration Number
- NCT03674541
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2018-04-27
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 44
- Registration Number
- NCT03510546
- Locations
- 🇩🇰
Department of Neurology Aarhus University Hospital, Aarhus, Midtjylland, Denmark
Pyridostigmine as Immunomodulator in People Living With HIV
- Conditions
- Interventions
- First Posted Date
- 2017-10-17
- Last Posted Date
- 2020-04-10
- Target Recruit Count
- 60
- Registration Number
- NCT03312244
- Locations
- 🇲🇽
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Tlalpan, Mexico
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.