Metoclopramide

Generic Name: Metoclopramide

Brand Names: Gimoti, Reglan

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₂₂ClN_₃O_₂

CAS Number: 364-62-5

Unique Ingredient Identifier: L4YEB44I46

Background: Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GER...

Indication: Metoclopramide in the oral tablet form is used for symptomatic treatment of both acute and recurrent diabetic gastroparesis, in addition to the treatment of gastroesophageal reflux disease (GERD) in patients who have failed to respond to traditional therapy. A nasal spray formulation is also indicated to treat adults with acute, recurrent diabetic gastropare...

Associated Conditions: Chemotherapy-Induced Nausea and Vomiting, Diabetic Gastroparesis, Dyspepsia, Flatulence, Gastroesophageal Reflux, Gastroparesis, Hiccups, Hyperacidity, Migraine, Nausea and vomiting, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Acute, recurrent Diabetic Gastroparesis, Gastric bezoar

Associated Therapies: Facilitation of small bowel intubation therapy, Gastric emptying for radiologic procedures

Clinical Trials

Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

Not Applicable

Terminated

Conditions: Nausea

Interventions: Drug: Ondansetron
Drug: Metoclopramide
Drug: Promethazine
Drug: Normal Saline

First Posted Date: 2008-04-10

Last Posted Date: 2013-10-30

Lead Sponsor: Vanderbilt University

Target Recruit Count: 171

Registration Number: NCT00655642

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

MgSO4 vs Metoclopramide for Headache in Pregnant Women

Phase 2

Withdrawn

Conditions: Headache

Interventions: Drug: magnesium sulfate
Drug: metoclopramide

First Posted Date: 2008-03-11

Last Posted Date: 2012-12-25

Lead Sponsor: Women and Infants Hospital of Rhode Island

Registration Number: NCT00632606

Locations: 🇺🇸
Women and Infants Hospital of Rhode Island, Providence, Rhode Island, United States

Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood

Phase 3

Withdrawn

Conditions: Migraine

Interventions: Drug: metoclopramide
Drug: ketoprofen
Drug: placebo

First Posted Date: 2007-11-14

Last Posted Date: 2017-08-24

Lead Sponsor: IRCCS Burlo Garofolo

Registration Number: NCT00557544

Locations: 🇮🇹
Edoardo Guglia, Trieste, Italy

The CRISIS Prevention Study

Phase 3

Terminated

Conditions: Sepsis

Interventions: Other: saline
Drug: Metoclopramide
Other: sterile water
Drug: Zinc
Dietary Supplement: Glutamine
Other: selenium
Dietary Supplement: whey-protein

First Posted Date: 2006-11-02

Last Posted Date: 2013-04-18

Lead Sponsor: Michael Dean

Target Recruit Count: 293

Registration Number: NCT00395161

Locations: 🇺🇸
Childrens Hospital of Los Angeles, Los Angeles, California, United States
🇺🇸
University of California Los Angeles Medical Center, Los Angeles, California, United States
🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

and more 4 locations

Prochlorperazine vs Metoclopramide

Phase 4

Completed

Conditions: Migraine

First Posted Date: 2006-08-16

Last Posted Date: 2018-04-17

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 76

Registration Number: NCT00364806

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Treatment of Acute Migraine Headache in Children

Phase 2

Completed

Conditions: Migrainous Headache

Interventions: Drug: Metoclopramide
Other: Placebo

First Posted Date: 2006-07-21

Last Posted Date: 2015-11-30

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 31

Registration Number: NCT00355394

Locations: 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Bowel Preparation and Prokinetics in Capsule Endoscopy

Phase 3

Conditions: Small Bowel Disease
Gastrointestinal Hemorrhage
Refractory Anemia

First Posted Date: 2006-01-11

Last Posted Date: 2007-09-24

Lead Sponsor: London North West Healthcare NHS Trust

Target Recruit Count: 150

Registration Number: NCT00275184

Locations: 🇬🇧
St Mark's Hospital, North West London Hospitals NHS Trust, London, United Kingdom

Metoclopramide Use in Very Low Birth Weight Newborns

Phase 4

Completed

Conditions: Infant, Premature

First Posted Date: 2005-10-20

Last Posted Date: 2017-08-25

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 30

Registration Number: NCT00242450

Locations: 🇨🇦
St Joseph's Hospital, London, Ontario, Canada

Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial

Not Applicable

Conditions: Post Concussive Syndrome
Post Concussive Headache

First Posted Date: 2005-10-12

Last Posted Date: 2006-12-05

Lead Sponsor: Vancouver General Hospital

Target Recruit Count: 40

Registration Number: NCT00237705

Locations: 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada

Metoclopramide to Treat Anemia in Patients With Myelodysplastic Syndrome (MDS)

Phase 2

Withdrawn

Conditions: Myelodysplastic Syndromes

First Posted Date: 2005-07-18

Last Posted Date: 2017-07-02

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Registration Number: NCT00120653

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
🇺🇸
University of Washington, Seattle, Washington, United States

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