Cyclic GMP
- Generic Name
- Cyclic GMP
- Drug Type
- Small Molecule
- Chemical Formula
- C10H12N5O7P
- CAS Number
- 7665-99-8
- Unique Ingredient Identifier
- H2D2X058MU
- Background
Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Cadrenal Therapeutics Plans Phase 3 Trial for Tecarfarin in LVAD Patients
• Cadrenal Therapeutics aims to initiate a Phase 3 clinical trial for tecarfarin in LVAD patients in 2025, following discussions with the FDA.
• Tecarfarin received FDA Orphan Drug Designation for preventing thromboembolism in LVAD patients and Fast Track designation for ESKD patients with AFib.
• The company is exploring collaborations to advance tecarfarin's clinical trial and improve anticoagulation outcomes for patients with rare cardiovascular conditions.
• Clinical data suggests tecarfarin may offer a safer alternative to warfarin for LVAD patients, addressing limitations of current anticoagulation treatments.
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