Protamine sulfate

Generic Name
Protamine sulfate
Brand Names
-
Drug Type
Biotech
Chemical Formula
-
CAS Number
9009-65-8
Unique Ingredient Identifier
0DE9724IHC
Background

Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years . Subsequently, because most invasive surgical procedures in...

Indication

Protamine sulfate is indicated for counteracting or reversing the anticoagulant effect of heparin as necessary . Such reversal may, for example, be required often before surgery; after renal hemodialysis; post open heart surgery; whenever excessive bleeding results from heparin use; and/or for the treatment of heparin overdosage, among other similar or relat...

Associated Conditions
Heparin overdose
Associated Therapies
-

Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI)

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2023-03-20
Last Posted Date
2024-05-31
Lead Sponsor
St. Antonius Hospital
Target Recruit Count
1000
Registration Number
NCT05774691
Locations
🇳🇱

Amsterdam University Medical Center, Amsterdam, Netherlands

🇧🇪

A.S.Z. Aalst, Aalst, Belgium

🇧🇪

University Hospitals Leuven, Leuven, Belgium

and more 3 locations

Systematic Evaluation of Protamine Doze in Cardiac Surgery

First Posted Date
2018-12-26
Last Posted Date
2018-12-31
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
100
Registration Number
NCT03787641
Locations
🇨🇦

London Health Sciences Centre, London, Ontario, Canada

Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation

First Posted Date
2017-05-04
Last Posted Date
2018-10-23
Lead Sponsor
University of Michigan
Target Recruit Count
153
Registration Number
NCT03140631
Locations
🇺🇸

Michigan Medicine, Ann Arbor, Michigan, United States

Protamine Sulfate During Transcatheter Aortic Valve Implantation

First Posted Date
2016-11-28
Last Posted Date
2020-10-22
Lead Sponsor
Medical University of Warsaw
Target Recruit Count
100
Registration Number
NCT02974660
Locations
🇵🇱

First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland

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