普鲁卡因 (Novocain)

概览

Procaine is a local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.

作用机制

Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

适应症

Used as a local anesthetic primarily in oral surgery

• Otalgia