Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Treatment of Acute Pseudophakic Cystoid Macular Edema: Bromfenac 0.09% Versus Diclofenac Sodium 0.1% Versus Ketorolac Tromethamine 0.5%
- Conditions
- Interventions
- First Posted Date
- 2008-01-16
- Last Posted Date
- 2009-03-19
- Lead Sponsor
- Bp Consulting, Inc
- Target Recruit Count
- 166
- Registration Number
- NCT00595543
- Locations
- 🇺🇸
Soll Eye Associates, Philadelphia, Pennsylvania, United States
Topical Voltaren in Otitis Externa
- First Posted Date
- 2007-08-30
- Last Posted Date
- 2016-04-20
- Lead Sponsor
- Sieff Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT00523120
- Locations
- 🇮🇱
Sieff Medical Center, Safed, Israel
Normothermia in Patients With Acute Cerebral Damage
- Conditions
- Locations
- 🇮🇹
Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
- Conditions
- Interventions
- First Posted Date
- 2007-05-22
- Last Posted Date
- 2017-05-01
- Lead Sponsor
- Norwegian University of Science and Technology
- Target Recruit Count
- 218
- Registration Number
- NCT00476593
- Locations
- 🇳🇴
Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
🇳🇴Department of Ophthalmology, St Olavs University Hospital, Trondheim, Norway
The Standard Care Versus Celecoxib Outcome Trial
- Conditions
- Interventions
- First Posted Date
- 2007-03-15
- Last Posted Date
- 2019-05-03
- Lead Sponsor
- University of Dundee
- Target Recruit Count
- 7297
- Registration Number
- NCT00447759
- Locations
- 🇳🇱
Julius Clinical Research, Zeist, Netherlands
🇬🇧University of Dundee, Dundee, United Kingdom
🇬🇧NHS Highlands, Inverness, United Kingdom
Diclofenac for the Prevention of Post-ERCP Pancreatitis in Higher Risk Patients
- First Posted Date
- 2007-01-29
- Last Posted Date
- 2015-09-22
- Lead Sponsor
- Queen's University
- Target Recruit Count
- 23
- Registration Number
- NCT00428025
- Locations
- 🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada
Feasibility of n-of-1 Trials - a Pilot Study
- Conditions
- First Posted Date
- 2006-09-04
- Last Posted Date
- 2006-09-04
- Lead Sponsor
- University of Bristol
- Target Recruit Count
- 10
- Registration Number
- NCT00371696
- Locations
- 🇬🇧
Southmead Hospital, Bristol, United Kingdom
Treatment of Breast Pain Using A Medication (Diclofenac) Applied to the Skin
- Conditions
- Interventions
- First Posted Date
- 2006-01-13
- Last Posted Date
- 2012-12-20
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 25
- Registration Number
- NCT00276419
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Non Steroidal Anti Inflammatory Treatment for Post Operative Pericardial Effusion
- First Posted Date
- 2005-11-01
- Last Posted Date
- 2009-08-03
- Lead Sponsor
- French Cardiology Society
- Target Recruit Count
- 200
- Registration Number
- NCT00247052
- Locations
- 🇫🇷
Hôpital Bligny, Briis sous forges, France
🇫🇷IRIS, Lyon, France
🇫🇷Hôpital Broussais, Paris, France
Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2006-10-11
- Lead Sponsor
- TNO
- Target Recruit Count
- 20
- Registration Number
- NCT00221052
- Locations
- 🇳🇱
TNO Quality of Life, Zeist, Netherlands
Drug Development Updates
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