Diclofenac

Generic Name: Diclofenac

Brand Names: Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₁₁Cl_₂NO_₂

CAS Number: 15307-86-5

Unique Ingredient Identifier: 144O8QL0L1

Background: Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...

Indication: Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...

Associated Conditions: Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis

Associated Therapies: -

Clinical Trials

The Effect of Diclofenac Potassium Insitu Gel Vs Calcium Hydroxide as Intra-canal Medications on Post-operative Pain and Anti-bacterial Effect

Not Applicable

Conditions: Post Operative Pain

Interventions: Drug: Diclofenac Potassium

First Posted Date: 2020-11-10

Last Posted Date: 2020-11-10

Lead Sponsor: Cairo University

Target Recruit Count: 44

Registration Number: NCT04622488

Locations: 🇪🇬
Faculty of Dentistry Cairo University, Cairo, El- Manial, Egypt

Sahastara Remedy Extract Capsule in Primary Osteoarthritis of Clinical Trial Phase II

Phase 2

Conditions: Osteoarthritis

Interventions: Drug: Sahastara remedy extract
Drug: Diclofenac

First Posted Date: 2020-10-19

Last Posted Date: 2020-10-19

Lead Sponsor: Mr NARIN KAKATUM

Target Recruit Count: 80

Registration Number: NCT04591795

Locations: 🇹🇭
Mr. NARIN KAKATUM, Bangkok, BKK, Thailand

Efficacy of Preoperative Diclofenac Potassium- Acetaminophen Combination on Anesthetic Success in Patients With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial

Not Applicable

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Placebo
Drug: Diclofenac potassium- acetaminophen combination
Drug: Diclofenac potassium

First Posted Date: 2020-10-19

Last Posted Date: 2020-10-30

Lead Sponsor: Cairo University

Target Recruit Count: 72

Registration Number: NCT04593160

Evaluation of Trans-mucosal Bio-adhesive Discs of Diclofenac Potassium on the Anesthetic Success and Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

Phase 4

Conditions: Irreversible Pulpitis
Postoperative Pain

Interventions: Drug: Diclofenac Potassium

First Posted Date: 2020-10-14

Last Posted Date: 2020-10-14

Lead Sponsor: Cairo University

Target Recruit Count: 48

Registration Number: NCT04585438

5% KOH Solution vs. Placebo and Diclofenac Gel for the Treatment of Actinic Keratosis

Phase 3

Completed

Conditions: Actinic Keratosis

Interventions: Device: Solcera
Device: Placebo
Drug: Solaraze

First Posted Date: 2020-09-17

Last Posted Date: 2024-03-05

Lead Sponsor: Infectopharm Arzneimittel GmbH

Target Recruit Count: 631

Registration Number: NCT04552327

Locations: 🇩🇪
Hautarztpraxis Leitz und Kollegen, Stuttgart, Germany
🇩🇪
Praxis Dres. K.-H. Vehring/U. Amann, Lingen, Germany
🇩🇪
Zentderma GBR, Mönchengladbach, Germany

and more 15 locations