Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.
- Conditions
- Interventions
- First Posted Date
- 2019-03-04
- Last Posted Date
- 2022-05-31
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 198
- Registration Number
- NCT03861611
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy
- First Posted Date
- 2019-02-05
- Last Posted Date
- 2019-02-05
- Lead Sponsor
- Taha Uçar
- Target Recruit Count
- 144
- Registration Number
- NCT03831321
- Locations
- 🇹🇷
Medeniyet University, Istanbul, Outside U.S./Canada, Turkey
Lidocaine Infusion in Hystroscopy
- First Posted Date
- 2019-01-31
- Last Posted Date
- 2020-01-28
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 44
- Registration Number
- NCT03825016
- Locations
- 🇪🇬
Ain Shams University Maternity Hospital, Cairo, Egypt
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
- Conditions
- Interventions
- First Posted Date
- 2018-12-20
- Last Posted Date
- 2024-05-17
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 90
- Registration Number
- NCT03781544
- Locations
- 🇨🇭
University Heart Center Zurich, Zurich, Switzerland
Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life
- Conditions
- Interventions
- First Posted Date
- 2018-11-19
- Last Posted Date
- 2018-11-19
- Lead Sponsor
- Near East University, Turkey
- Target Recruit Count
- 60
- Registration Number
- NCT03745599
- Locations
- 🇹🇷
Abdullah AlAlwani, Mersin, Turkey
Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
- Conditions
- Interventions
- First Posted Date
- 2018-07-30
- Last Posted Date
- 2021-07-20
- Target Recruit Count
- 100
- Registration Number
- NCT03605914
- Locations
- 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States
Diclofenac for Prevention of Post-ERC Pancreatitis
- First Posted Date
- 2018-07-23
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- Karolinska Institutet
- Target Recruit Count
- 1000
- Registration Number
- NCT03595150
Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-04-10
- Last Posted Date
- 2023-03-20
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 72
- Registration Number
- NCT03493490
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis
- Conditions
- Interventions
- First Posted Date
- 2018-03-22
- Last Posted Date
- 2020-09-22
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 9
- Registration Number
- NCT03473665
- Locations
- 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States
Clinical Trial Comparing Intravenous and Oral Diclofenac and Pharmacokinetics
- First Posted Date
- 2018-03-21
- Last Posted Date
- 2018-03-22
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 300
- Registration Number
- NCT03472339
- Locations
- 🇶🇦
Isma Qureshi, Doha, Qatar
Drug Development Updates
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