Apremilast

Generic Name
Apremilast
Brand Names
Otezla, Apremilast Accord
Drug Type
Small Molecule
Chemical Formula
C22H24N2O7S
CAS Number
608141-41-9
Unique Ingredient Identifier
UP7QBP99PN
Background

Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as Roflumilast and Crisaborole. Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted a new FDA approval for the tr...

Indication

Apremilast is indicated for the treatment of adults with active psoriatic arthritis and adults with oral ulcers associated with Behcet's Disease. In addition, apremilast is indicated for the treatment of plaque psoriasis, of any severity, in adult patients who are candidates for phototherapy or systemic therapy.

Associated Conditions
Psoriasis Vulgaris (Plaque Psoriasis), Active Psoriatic arthritis, Ulceration of the mouth
Associated Therapies
-

Real World Study on the Efficacy and Safety of Apremilast in Chinese Patients With Moderate to Severe Plaque Psoriasis, a Multi Center, Prospective, Observational Trial(REACT)

Not yet recruiting
Conditions
Interventions
First Posted Date
2023-05-18
Last Posted Date
2023-05-18
Lead Sponsor
First Hospital of China Medical University
Target Recruit Count
360
Registration Number
NCT05863273
Locations
🇨🇳

China-Japan Friendship Hospital, Beijing, China

🇨🇳

the First Hospital of China Medical University, Shenyang, China

A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis

First Posted Date
2023-03-14
Last Posted Date
2024-12-16
Lead Sponsor
Amgen
Target Recruit Count
48
Registration Number
NCT05767047
Locations
🇮🇱

Meir Medical Center, Kfar Saba, Israel

🇬🇷

General Hospital of Thessaloniki Ippokrateio, Thessaloniki, Greece

🇪🇸

Hospital Universitari i Politecnic La Fe, Valencia, Comunidad Valenciana, Spain

and more 3 locations

A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis

Recruiting
Conditions
Interventions
First Posted Date
2023-02-27
Last Posted Date
2024-07-23
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
1500
Registration Number
NCT05744466
Locations
🇺🇸

Local Institution, Waltham, Massachusetts, United States

A Study to Assess the Efficacy and Safety of Apremilast in Japanese Pediatric Participants With Moderate to Severe Plaque Psoriasis

Phase 3
Recruiting
Conditions
Interventions
First Posted Date
2022-10-04
Last Posted Date
2024-12-18
Lead Sponsor
Amgen
Target Recruit Count
33
Registration Number
NCT05565560
Locations
🇯🇵

Fukuoka University Hospital, Fukuoka-shi, Fukuoka, Japan

🇯🇵

Hospital of the University of Occupational and Environmental Health Japan, Kitakyushu-shi, Fukuoka, Japan

🇯🇵

Kurume University Hospital, Kurume-shi, Fukuoka, Japan

and more 24 locations

Phase 3, Randomized Study of Apremilast in Japanese Participants With Palmoplantar Pustulosis (PPP)

Phase 3
Completed
Conditions
Interventions
First Posted Date
2021-12-30
Last Posted Date
2024-11-05
Lead Sponsor
Amgen
Target Recruit Count
176
Registration Number
NCT05174065
Locations
🇯🇵

Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan

🇯🇵

Seibo International Catholic Hospital, Shinjuku-ku, Tokyo, Japan

🇯🇵

Medical corporation kojinkai Chitose dermatology and plastic surgery clinic, Chitose-shi, Hokkaido, Japan

and more 37 locations

Study of Subcutaneous Risankizumab Injection Compared to Oral Apremilast Tablets to Assess Change in Disease Activity And Adverse Events in Adult Participants With Moderate Plaque Psoriasis Who Are Candidates for Systemic Therapy

Phase 4
Completed
Conditions
Interventions
First Posted Date
2021-06-01
Last Posted Date
2024-04-30
Lead Sponsor
AbbVie
Target Recruit Count
352
Registration Number
NCT04908475
Locations
🇺🇸

Epiphany Dermatology of Kansas LLC /ID# 229221, Overland Park, Kansas, United States

🇺🇸

Center for Clinical Studies - Houston (Binz) /ID# 229272, Houston, Texas, United States

🇺🇸

UC Davis Health /ID# 229133, Sacramento, California, United States

and more 51 locations

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

Phase 3
Active, not recruiting
Conditions
Interventions
First Posted Date
2021-06-01
Last Posted Date
2024-11-01
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
729
Registration Number
NCT04908189
Locations
🇦🇷

Local Institution - 0200, Buenos Aires, Argentina

🇦🇺

Local Institution - 0018, Paramatta, New South Wales, Australia

🇦🇺

Local Institution - 0002, Camberwell, Victoria, Australia

and more 144 locations

Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis

First Posted Date
2021-03-18
Last Posted Date
2024-12-13
Lead Sponsor
Amgen
Target Recruit Count
60
Registration Number
NCT04804553
Locations
🇧🇪

Centre Hospitalier Regional de la Citadelle, Liege, Belgium

🇦🇹

Landeskrankenhaus Bregenz, Bregenz, Austria

🇧🇪

Universitair Ziekenhuis Gent, Gent, Belgium

and more 39 locations

Study of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalized Patients

First Posted Date
2020-10-19
Last Posted Date
2022-06-29
Lead Sponsor
Amgen
Target Recruit Count
515
Registration Number
NCT04590586
Locations
🇺🇸

The University of Iowa, Iowa City, Iowa, United States

🇺🇸

Sharp Chula Vista Medical Center, Chula Vista, California, United States

🇷🇺

SPb SBIH "Alexandrovskaya City Hospital", Saint Petersburg, Russian Federation

and more 56 locations
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