Chenodeoxycholic acid
- Generic Name
- Chenodeoxycholic acid
- Brand Names
- Chenodal, Chenodeoxycholic acid Leadiant (previously known as Chenodeoxycholic acid sigma-tau)
- Drug Type
- Small Molecule
- Chemical Formula
- C24H40O4
- CAS Number
- 474-25-9
- Unique Ingredient Identifier
- 0GEI24LG0J
- Background
Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decrease the formation of gallstones. It can also reduce the amount of other bile acids that can be harmful to liver cells when levels are elevated.
- Indication
Chenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.
- Associated Conditions
- Radiolucent Cholesterol gallstones
- Associated Therapies
- -
Phase II Study of Cholesterol- and Cholestanol-Free Diet, Lovastatin, and Chenodeoxycholic Acid for Cerebrotendinous Xanthomatosis
- Conditions
- Cerebrotendinous Xanthomatosis
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 5
- Registration Number
- NCT00004346
- Locations
- 🇺🇸
Oregon Health and Science University, Portland, Oregon, United States
Study of Bile Acids in Patients With Peroxisomal Disorders
- Conditions
- AdrenoleukodystrophyBifunctional Enzyme DeficiencyInfantile Refsum's DiseaseZellweger Syndrome
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 25
- Registration Number
- NCT00004442
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