Didanosine

Generic Name
Didanosine
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C10H12N4O3
CAS Number
69655-05-6
Unique Ingredient Identifier
K3GDH6OH08
Background

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Indication

For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.

Associated Conditions
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Associated Therapies
-

The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
300
Registration Number
NCT00001087
Locations
🇺🇸

Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois, United States

🇺🇸

Cook County Hosp. CORE Ctr., Chicago, Illinois, United States

🇺🇸

Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, United States

and more 3 locations

A Study of ddI in Patients With AIDS Who Become Sicker While Taking Zidovudine

First Posted Date
2001-08-31
Last Posted Date
2007-10-02
Lead Sponsor
Bristol-Myers Squibb
Registration Number
NCT00002274
Locations
🇺🇸

Bristol - Myers Squibb Co, Princeton, New Jersey, United States

A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2007-10-02
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
200
Registration Number
NCT00002168
Locations
🇺🇸

Univ of Nebraska, Omaha, Nebraska, United States

🇺🇸

Anderson Clinical Research, Washington, District of Columbia, United States

🇵🇷

Hosp Regional de Ponce - Area Vieja, Ponce, Puerto Rico

and more 10 locations

A Treatment IND (Investigational New Drug) Protocol for the Use of Videx (2',3'-Dideoxyinosine, ddI) in Patients With Acquired Immunodeficiency Syndrome (AIDS) or AIDS- Related Complex (ARC) Who Are Intolerant to Zidovudine (Retrovir)

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2007-08-16
Lead Sponsor
Bristol-Myers Squibb
Registration Number
NCT00002028
Locations
🇺🇸

Bristol - Myers Squibb Co, Princeton, New Jersey, United States

A Phase I Safety and Pharmacokinetics Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Infants and Children With AIDS or Symptomatic HIV Infection

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2008-08-26
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
25
Registration Number
NCT00000669
Locations
🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

🇺🇸

The Regional Medical Ctr, Memphis, Memphis, Tennessee, United States

🇺🇸

Univ TX Health Science Ctr, Houston, Texas, United States

and more 2 locations

The Safety and Effectiveness of Didanosine Plus Stavudine Plus Delavirdine Mesylate Plus MKC-442 in HIV-Infected Patients Who Have Not Had Success With Protease Inhibitors

Phase 2
Terminated
Conditions
First Posted Date
2001-08-31
Last Posted Date
2008-08-14
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
25
Registration Number
NCT00002420
Locations
🇺🇸

Pacific Oaks Med Group, Beverly Hills, California, United States

The Safety and Effectiveness of Didanosine Plus Stavudine Plus Nevirapine Combined With MKC-442 in HIV-Infected Patients Who Have Not Had Success With Protease Inhibitors

Phase 2
Terminated
Conditions
First Posted Date
2001-08-31
Last Posted Date
2008-08-14
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
25
Registration Number
NCT00002418
Locations
🇺🇸

Univ of Colorado / Health Science Ctr, Denver, Colorado, United States

🇺🇸

Brown Univ School of Medicine, Providence, Rhode Island, United States

🇺🇸

AIDS Research Consortium of Atlanta, Atlanta, Georgia, United States

and more 2 locations

A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV Infection

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2008-08-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
96
Registration Number
NCT00000760
Locations
🇺🇸

UCSD, San Diego, California, United States

🇺🇸

Case Western Reserve Univ, Cleveland, Ohio, United States

🇺🇸

Harvard (Massachusetts Gen Hosp), Boston, Massachusetts, United States

and more 1 locations

The Safety and Effectiveness of Clarithromycin Plus Zidovudine or Dideoxyinosine in the Treatment of Mycobacterium Avium Complex (MAC) Infections in Children With AIDS

First Posted Date
2001-08-31
Last Posted Date
2008-08-04
Lead Sponsor
Abbott
Target Recruit Count
24
Registration Number
NCT00000971
Locations
🇺🇸

Children's Hosp of Los Angeles, Los Angeles, California, United States

🇺🇸

Natl Cancer Institute / HIV / AIDS Malignancy Branch, Bethesda, Maryland, United States

A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
654
Registration Number
NCT00001029
Locations
🇺🇸

Harbor-UCLA Med. Ctr. CRS, Torrance, California, United States

🇺🇸

Cook County Hosp. CORE Ctr., Chicago, Illinois, United States

🇺🇸

Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois, United States

and more 34 locations
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