A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
HRS Palm Beach County Public Health Unit, West Palm Beach, Florida, United States
Children's Hosp of Washington DC, Washington, District of Columbia, United States
Howard Univ Hosp, Washington, District of Columbia, United States
AIDS Research Consortium of Atlanta, Inc. (ARCA) AIEDRP CRS, Atlanta, Georgia, United States
Feinberg School of Medicine, HIV/ACTU AIEDRP CRS, Chicago, Illinois, United States
Rush Univ. Med. Ctr., Dept. of Infectious Disease AIEDRP CRS, Chicago, Illinois, United States
AIDS Research Consortium of Atlanta, Atlanta, Georgia, United States
Albany Med College / AIDS Treatment Ctr, Albany, New York, United States
Univ of Texas Southwestern Med Ctr of Dallas, Dallas, Texas, United States
Louisiana Comm AIDS Rsch Prog / Tulane Univ Med, New Orleans, Louisiana, United States
Washington Reg AIDS Prog / Dept of Infect Dis, Washington, District of Columbia, United States
Harlem AIDS Treatment Grp / Harlem Hosp Ctr, New York, New York, United States
USC CRS, Los Angeles, California, United States
Regional Center for Infectious Disease, Wendover Medical Center CRS, Greensboro, North Carolina, United States
Beth Israel Deaconess - East Campus A0102 CRS, Boston, Massachusetts, United States
Stanford CRS, Palo Alto, California, United States
Santa Clara Valley Med. Ctr., San Jose, California, United States
San Mateo County AIDS Program, San Mateo, California, United States
USC CRS, Los Angeles, California, United States
Univ. of Miami AIDS CRS, Miami, Florida, United States
St. Louis ConnectCare, Infectious Diseases Clinic, Saint Louis, Missouri, United States
Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, United States
Bmc Actg Crs, Boston, Massachusetts, United States
Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston, Massachusetts, United States
Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States
Hemophilia Ctr of Western PA / Univ of Pittsburgh, Pittsburgh, Pennsylvania, United States
Univ of Pittsburgh Med School, Pittsburgh, Pennsylvania, United States
Univ of Washington, Seattle, Washington, United States
Palo Alto Veterans Adm Med Ctr / Stanford Univ, Palo Alto, California, United States
Whitman - Walker Clinic, Washington, District of Columbia, United States
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