A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States
Cook County Hosp, Chicago, Illinois, United States
Chicago Children's Memorial Hosp, Chicago, Illinois, United States
Harbor-UCLA Med. Ctr. CRS, Torrance, California, United States
Weiss Memorial Hosp., Chicago, Illinois, United States
Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, United States
Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium, San Jose, California, United States
San Mateo AIDS Program / Stanford Univ, Stanford, California, United States
Bellevue Hosp / New York Univ Med Ctr, New York, New York, United States
Schneider Children's Hosp, New Hyde Park, New York, United States
Children's Hosp of Boston, Boston, Massachusetts, United States
Univ of Medicine & Dentistry of New Jersey / Univ Hosp, Newark, New Jersey, United States
Bmc Actg Crs, Boston, Massachusetts, United States
Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, United States
University of Washington AIDS CRS, Seattle, Washington, United States
Univ of Nebraska Med Ctr, Omaha, Nebraska, United States
Case Western Reserve Univ, Cleveland, Ohio, United States
Thomas Jefferson Univ Hosp, Philadelphia, Pennsylvania, United States
SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York, United States
USC CRS, Los Angeles, California, United States
UCSD Maternal, Child, and Adolescent HIV CRS, San Diego, California, United States
Ucsd, Avrc Crs, San Diego, California, United States
Univ of Illinois, Chicago, Illinois, United States
Univ of Maryland at Baltimore, Baltimore, Maryland, United States
Duke Univ Med Ctr, Durham, North Carolina, United States
AIDS Research Consortium of Atlanta, Atlanta, Georgia, United States
AIDS Research Alliance - Chicago, Chicago, Illinois, United States
Community Consortium of San Francisco, San Francisco, California, United States
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