Overview
Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate . This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Background
Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate . This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Indication
临床上主要用于脓胸、血胸、外科炎症、溃疡、创伤性损伤、瘘管等所产生的局部水肿、血肿、脓肿等，虹膜睫状体炎、急性泪囊炎、视网膜周围炎、眼外伤等。喷雾吸入，用于呼吸道疾病。因对蛇毒蛋白（蛇毒的主要毒成分）有水解作用，故有将本品用于治疗毒蛇咬伤，曾试用于竹叶青、银环蛇、眼镜蛇、蝮蛇等毒蛇的各型病例。
Associated Conditions
- Inflammatory Reaction of the genitourinary tract
- Osteoarthritis (OA)
- Thrombophlebitis
- Traumatic Injuries
- Localized soft tissue rheumatism
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Trypsin for Injection | 国药准字H31022017 | 化学药品 | 注射剂（冻干） | 9/27/2022 | |
| Trypsin for Injection | 国药准字H31022019 | 化学药品 | 注射剂（冻干） | 8/31/2022 | |
| Trypsin for Injection | 国药准字H31022016 | 化学药品 | 注射剂（冻干） | 9/27/2022 | |
| Trypsin for Injection | 国药准字H31022018 | 化学药品 | 注射剂（冻干） | 8/31/2022 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Orthoplex D.E.F. Tablets | 19973 | Medicine | A | 10/3/1991 |