Overview
Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate . This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Indication
临床上主要用于脓胸、血胸、外科炎症、溃疡、创伤性损伤、瘘管等所产生的局部水肿、血肿、脓肿等，虹膜睫状体炎、急性泪囊炎、视网膜周围炎、眼外伤等。喷雾吸入，用于呼吸道疾病。因对蛇毒蛋白（蛇毒的主要毒成分）有水解作用，故有将本品用于治疗毒蛇咬伤，曾试用于竹叶青、银环蛇、眼镜蛇、蝮蛇等毒蛇的各型病例。
Associated Conditions
- Inflammatory Reaction of the genitourinary tract
- Osteoarthritis (OA)
- Thrombophlebitis
- Traumatic Injuries
- Localized soft tissue rheumatism
Clinical Trials
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No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
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| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Orthoplex D.E.F. Tablets | 19973 | Medicine | A | 10/3/1991 |
Health Canada Drug Approvals
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| No Health Canada approvals found for this drug. | |||||
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| DOSIL ENZIMATICO CAPSULAS | Laboratorios Llorens S.A. | 48583 | CÁPSULA DURA | Medicamento Sujeto A Prescripción Médica | Not Commercialized |
| DERTRASE POMADA | Laboratorios Salvat S.A. | 32935 | POMADA | Medicamento Sujeto A Prescripción Médica | Not Commercialized |
Philippines FDA Drug Approvals
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| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
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| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
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| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
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| No UK EMC drug information found for this drug. | |||||
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