Linaclotide
- Generic Name
- Linaclotide
- Brand Names
- Constella, Linzess
- Drug Type
- Small Molecule
- Chemical Formula
- C59H79N15O21S6
- CAS Number
- 851199-59-2
- Unique Ingredient Identifier
- N0TXR0XR5X
- Background
Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist. Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from Escherichia coli, the first natural ligand that...
- Indication
Linaclotide is indicated for the treatment of irritable bowel syndrome with constipation in adults. This indication is approved in the US, Canada, and Europe.
In the US and Canada, it is also indicated for the treatment of chronic idiopathic constipation in adults.
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- Associated Conditions
- Functional Constipation (FC), Irritable Bowel Syndrome With Constipation (IBS-C), Chronic idiopathic constipation (CIC)
- Associated Therapies
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