Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
- Associated Conditions
- -
- Associated Therapies
- -
An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers
- Conditions
- Heart Diseases
- Interventions
- First Posted Date
- 2019-03-20
- Last Posted Date
- 2023-04-03
- Lead Sponsor
- Microvascular Therapeutics, LLC
- Target Recruit Count
- 16
- Registration Number
- NCT03882359
- Locations
- 🇺🇸
University of Nebraska Medical Center, Omaha, Nebraska, United States
🇺🇸Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States
DEF-314 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY
- First Posted Date
- 2018-06-27
- Last Posted Date
- 2020-12-17
- Lead Sponsor
- Lantheus Medical Imaging
- Target Recruit Count
- 153
- Registration Number
- NCT03571672
- Locations
- 🇺🇸
Alfieri Cardiology, Wilmington, Delaware, United States
🇺🇸Banner University of Arizona Medical Center, Tucson, Arizona, United States
🇺🇸Weill Cornell Medical Center, New York, New York, United States
Academic-Industrial Partnership for Translation of Acoustic Angiography
- First Posted Date
- 2018-06-01
- Last Posted Date
- 2022-04-01
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Target Recruit Count
- 20
- Registration Number
- NCT03544268
- Locations
- 🇺🇸
UNC Hospitals, Chapel Hill, North Carolina, United States
Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement
- Conditions
- Cardiac CatheterizationBlood PressureHeart VentriclesEchocardiographyHeart Failure
- Interventions
- First Posted Date
- 2017-08-09
- Last Posted Date
- 2019-07-10
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 56
- Registration Number
- NCT03243942
- Locations
- 🇺🇸
Thomas Jefferson University and Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Red Light Treatment in Peripheral Artery Disease
- Conditions
- VasodilationPeripheral Artery DiseaseClaudication, Intermittent
- Interventions
- Device: Red Light (670 nm energy)Drug: Octafluoropropane
- First Posted Date
- 2017-06-29
- Last Posted Date
- 2024-04-18
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 40
- Registration Number
- NCT03203239
- Locations
- 🇺🇸
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Contrast-enhanced Ultrasound for Complex Kidney Lesion Diagnosis in Patients With CKD Extension
- Conditions
- Chronic Kidney DiseasesCystic Kidney Disease
- Interventions
- First Posted Date
- 2017-06-22
- Last Posted Date
- 2021-07-21
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 25
- Registration Number
- NCT03196076
- Locations
- 🇺🇸
University of North Carolina of Chapel hill, Chapel Hill, North Carolina, United States
Cystic Breast Masses by Contrast Enhanced Ultrasound (CEUS)
- First Posted Date
- 2016-09-02
- Last Posted Date
- 2018-05-15
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 135
- Registration Number
- NCT02887937
- Locations
- 🇺🇸
USC Department of Radiology, Los Angeles, California, United States
Contrast-enhanced Ultrasound of the Kidney
- Conditions
- Chronic Kidney DiseaseCystic Kidney Disease
- Interventions
- First Posted Date
- 2016-02-18
- Last Posted Date
- 2019-09-26
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 63
- Registration Number
- NCT02684435
- Locations
- 🇺🇸
University of North Carolina of Chapel hill, Chapel Hill, North Carolina, United States
🇺🇸Vanderbilt University, Nashville, Tennessee, United States
Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
- Conditions
- HealthyPhysiology
- Interventions
- First Posted Date
- 2016-02-03
- Last Posted Date
- 2017-05-12
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 19
- Registration Number
- NCT02672722
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
Contrast Enhanced Intraoperative Ultrasound for Detection and Characterization of Renal Mass Undergoing Open Partial Nephrectomy
- Conditions
- Kidney Cancer
- Interventions
- First Posted Date
- 2013-07-10
- Last Posted Date
- 2016-04-14
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 11
- Registration Number
- NCT01894607
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Drug Development Updates
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