Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma
- Conditions
- Bone SarcomaRetroperitoneal SarcomaAdult Soft Tissue Sarcoma
- Interventions
- Procedure: Real-Time CEUSProcedure: SWEDevice: Philips Shear Wave Elastography
- First Posted Date
- 2015-03-10
- Last Posted Date
- 2024-01-23
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 25
- Registration Number
- NCT02384473
- Locations
- 🇺🇸
USC Norris Comprehensive Cancer Center, Los Angeles, California, United States
Feasibility of Ultrasound Microbubble Contrast-Enhanced (CEUS) Sentinel Lymph Node Imaging With Guided Biopsy in Breast Cancer Patients
- Conditions
- Breast Cancer
- Interventions
- Device: Contrast-Enhanced Ultrasound (CEUS)Procedure: Biopsy + Radioactive Seed PlacementBehavioral: Phone Call
- First Posted Date
- 2014-12-22
- Last Posted Date
- 2017-06-20
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 21
- Registration Number
- NCT02321527
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Myocardial Perfusion Echocardiography to Detect Human Heart Transplant Rejection
- First Posted Date
- 2014-11-25
- Last Posted Date
- 2023-07-27
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 10
- Registration Number
- NCT02300870
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
CeVUS With Intravesical Administration of OPTISON TM (Trademark) in Children
- First Posted Date
- 2014-07-31
- Last Posted Date
- 2018-11-27
- Lead Sponsor
- Kassa Darge
- Target Recruit Count
- 31
- Registration Number
- NCT02204917
- Locations
- 🇺🇸
Department of Radiology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study
- Conditions
- Liver Cirrhosis and Acute Kidney Injury
- Interventions
- First Posted Date
- 2014-05-26
- Last Posted Date
- 2014-05-26
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 25
- Registration Number
- NCT02147470
- Locations
- 🇺🇸
University of Virginia Health System, Charlottesville, Virginia, United States
Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy
- First Posted Date
- 2014-04-16
- Last Posted Date
- 2025-05-06
- Target Recruit Count
- 17
- Registration Number
- NCT02115607
- Locations
- 🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Neural Mechanism of Aldosterone-induced Insulin Resistance
- Conditions
- Hypertension
- Interventions
- Drug: Human Recombinant Regular Insulin infusionProcedure: Flow mediated vasodilationDrug: Dextrose infusionProcedure: Endothelial cell collectionProcedure: Microvascular perfusion assessment using DefinityProcedure: Microneurography
- First Posted Date
- 2014-04-02
- Last Posted Date
- 2023-03-15
- Lead Sponsor
- Wanpen Vongpatanasin
- Registration Number
- NCT02102243
- Locations
- 🇺🇸
UT Southwestern Medical Center, Dallas, Texas, United States
Contrast-Enhanced Ultrasound in Human Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Device: Contrast Enhanced Ultrasound
- First Posted Date
- 2014-02-12
- Last Posted Date
- 2015-06-15
- Lead Sponsor
- University of Michigan
- Registration Number
- NCT02061163
- Locations
- 🇺🇸
University of Michigan C.S. Mott Children's Hospital, Ann Arbor, Michigan, United States
Contrast Enhanced Intraoperative Ultrasound for Detection and Characterization of Renal Mass Undergoing Open Partial Nephrectomy
- Conditions
- Kidney Cancer
- Interventions
- First Posted Date
- 2013-07-10
- Last Posted Date
- 2016-04-14
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 11
- Registration Number
- NCT01894607
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Open-label Pilot Evaluating Renal Lesions w/ Contrast-enhaced US in Patients w/ Renal Cancer
- Conditions
- Kidney Cancer
- Interventions
- Procedure: Contrast-enhanced Ultrasound
- First Posted Date
- 2012-12-18
- Last Posted Date
- 2017-03-17
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Target Recruit Count
- 48
- Registration Number
- NCT01751529
- Locations
- 🇺🇸
Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States
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