Chlordiazepoxide
- Generic Name
- Chlordiazepoxide
- Brand Names
- Chlorax, Librax
- Drug Type
- Small Molecule
- Chemical Formula
- C16H14ClN3O
- CAS Number
- 58-25-3
- Unique Ingredient Identifier
- 6RZ6XEZ3CR
- Background
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
- Indication
Chlordiazepoxide is indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
In combination with amitriptyline, chlordiazepoxide is indicated for the treatment of moderate to severe depression. In combination with clidinium, chlordiazepoxide is indicated to control emotional and somatic factors in gastrointestinal disorders, and is used as adjunctive therapy in the treatment of peptic ulcer, irritable bowel syndrome and acute enterocolitis.
- Associated Conditions
- Alcohol Withdrawal Syndrome, Anxiety Disorders, Depression, Irritable Bowel Syndrome (IBS), Peptic Ulcer Disease, Preoperative Anxiety, Acute Enterocolitis
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia
- Conditions
- Drug Induced Liver Injury
- Interventions
- Procedure: Plaslna exchangeProcedure: Liver transplantation
- First Posted Date
- 2025-04-10
- Last Posted Date
- 2025-04-10
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 232
- Registration Number
- NCT06922669
- Locations
- 🇨🇳
Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area), Shenyang, Liaoning, China
Impact of Silymarin Adjunct Therapy on Proteinuria in Type 2 Diabetic Patients on RAS Inhibitors
- First Posted Date
- 2024-05-22
- Last Posted Date
- 2024-05-22
- Lead Sponsor
- Lahore General Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT06425705
- Locations
- 🇵🇰
Lahore General Hospital, Lahore, Lahore, Punjab, Pakistan
Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases
- Conditions
- Psoriatic ArthritisRheumatoid ArthritisPsoriasis
- Interventions
- Drug: Placebo
- First Posted Date
- 2024-02-26
- Last Posted Date
- 2024-02-26
- Lead Sponsor
- Phramongkutklao College of Medicine and Hospital
- Target Recruit Count
- 72
- Registration Number
- NCT06277635
- Locations
- 🇹🇭
Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand, 10400, Bangkok, Thailand
Silymarin for the Prevention of Atrial Fibrillation After Cardiac Surgery
- First Posted Date
- 2023-11-02
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- University of Novi Sad
- Target Recruit Count
- 160
- Registration Number
- NCT06114719
- Locations
- 🇷🇸
Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, Serbia
Effect of Silymarin in Metastatic Colorectal Cancer Patients
- First Posted Date
- 2022-11-30
- Last Posted Date
- 2023-12-22
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 64
- Registration Number
- NCT05631041
- Locations
- 🇪🇬
faculty of Pharmacy , Tanta University, Tanta, Egypt
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
- Conditions
- Peripheral NeuropathyCardiac ToxicitiesCognitive ImpairmentHepatic ToxicityBreast Cancer
- Interventions
- Drug: Placebo
- First Posted Date
- 2022-10-26
- Last Posted Date
- 2022-10-26
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 56
- Registration Number
- NCT05595109
- Locations
- 🇪🇬
Tanta university, Tanta, Egypt
Silymarin in COVID-19 Patients Admitted to Hospital With Elevated Liver Enzymes
- First Posted Date
- 2021-03-25
- Last Posted Date
- 2022-08-03
- Lead Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
- Target Recruit Count
- 30
- Registration Number
- NCT04816682
- Locations
- 🇸🇰
University Hospital Bratislava, Bratislava, Slovakia
🇸🇰F.D.Roosevelt Teaching Hospital, Banska Bystrica, Slovakia
Silymarin in COVID-19 Pneumonia
- First Posted Date
- 2020-05-19
- Last Posted Date
- 2020-08-18
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 50
- Registration Number
- NCT04394208
- Locations
- 🇪🇬
Cairo University, Giza, Cairo, Egypt
Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR
- Conditions
- Fibrosis, Liver
- Interventions
- First Posted Date
- 2018-09-06
- Last Posted Date
- 2018-11-27
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 400
- Registration Number
- NCT03659058
TONKA Versus Legalon for Lowering Hepatic Enzymes in Liver Function Disorder Patients.
- First Posted Date
- 2017-07-13
- Last Posted Date
- 2018-10-23
- Lead Sponsor
- Nhat Nhat Pharmaceutical Company
- Target Recruit Count
- 140
- Registration Number
- NCT03216668
- Locations
- 🇻🇳
Hue Central General Hospital, Hue, Vietnam
Drug Development Updates
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