硝酸异山梨酯 (Bidil, Dilatrate, Isordil)

概览

Isosorbide dinitrate is a vasodilator used to treat angina in coronary artery disease.

作用机制

Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3',5'-monophosphate (cGMP). cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation.

适应症

For the prevention of angina pectoris due to coronary artery disease.

• Angina Pectoris
• Heart Failure