Overview
Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Indication
For treatment of depression, including the depressed phase of bipolar depression, psychotic depression, and involutional melancholia, and may also be helpful in treating certain patients suffering severe depressive neurosis.
Associated Conditions
- Anxiety
- Bipolar Disorder (BD)
- Depression
- Major Depressive Disorder (MDD)
- Persistent Depressive Disorder (Dysthymia)
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2015/03/02 | Phase 3 | Terminated |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| PMS-MAPROTILINE | 02231559 | Tablet - Oral | 10 MG / TAB | N/A | |
| TEVA-MAPROTILINE | teva canada limited | 02158612 | Tablet - Oral | 25 MG | 12/31/1995 |
| PMS-MAPROTILINE | 02231561 | Tablet - Oral | 50 MG / TAB | N/A | |
| LUDIOMIL TAB 10MG | novartis pharmaceuticals canada inc | 00641855 | Tablet - Oral | 10 MG | 12/31/1985 |
| LUDIOMIL TAB 75MG | novartis pharmaceuticals canada inc | 00360511 | Tablet - Oral | 75 MG / TAB | 12/31/1976 |
| PMS-MAPROTILINE | 02231562 | Tablet - Oral | 75 MG / TAB | N/A | |
| TEVA-MAPROTILINE | teva canada limited | 02158620 | Tablet - Oral | 50 MG | 12/31/1995 |
| TEVA-MAPROTILINE | teva canada limited | 02158639 | Tablet - Oral | 75 MG | 12/31/1995 |
| LUDIOMIL TAB 25MG | novartis pharmaceuticals canada inc | 00360481 | Tablet - Oral | 25 MG / TAB | 12/31/1976 |
| LUDIOMIL TAB 50MG | novartis pharmaceuticals canada inc | 00360503 | Tablet - Oral | 50 MG / TAB | 12/31/1976 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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