Pancrelipase

Generic Name
Pancrelipase
Brand Names
-
Drug Type
Biotech
Chemical Formula
-
CAS Number
53608-75-6
Unique Ingredient Identifier
FQ3DRG0N5K
Background

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010. For further information on the components of this mixture p...

Indication

The use of pancrelipase amylase is part of the pancreatic enzyme replacement therapy. This therapy is indicated for the treatment of pancreatic insufficiency attributed to cystic fibrosis, chronic pancreatitis or any other medically defined pancreatic disease that might require it. Pancreatic diseases are associated with the deterioration of pancreatic paren...

Associated Conditions
Aerophagy, Deficiency Digestive enzymes, Diarrhea, Dyspepsia, Exocrine Pancreatic Insufficiency, Flatulence, Gastrointestinal Discomfort, Pancreatic Insufficiency, Post Operative Gas, Pre-operative Gas, Fat malabsorption, Meteorism
Associated Therapies
Bile Duct Disorders, Carbohydrate Digestion, Digestive Aid, Fat Digestion, Liver Metabolism, Protein Digestion

Trial of Pancreatic Enzyme Supplements (Pancrelipase) for Treating Pain in Patients With Chronic Pancreatitis

Phase 2
Withdrawn
Conditions
Interventions
First Posted Date
2016-03-11
Last Posted Date
2018-02-27
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Registration Number
NCT02706236
Locations
🇺🇸

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States

Pancreatic Enzyme Supplementation for Celiac Disease

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2015-06-18
Last Posted Date
2021-05-12
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
21
Registration Number
NCT02475369
Locations
🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Improving Treatment of Nontuberculous Mycobacterial Infection in Cystic Fibrosis

First Posted Date
2015-02-26
Last Posted Date
2021-02-11
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
31
Registration Number
NCT02372383
Locations
🇺🇸

Children's Hospital Colroado, Aurora, Colorado, United States

A Study to Assess the Effect of Creon® on Pancreatic Exocrine Insufficiency in Subjects With Diabetes Mellitus Type 2

First Posted Date
2013-12-12
Last Posted Date
2014-06-20
Lead Sponsor
Abbott
Registration Number
NCT02009410
Locations
🇪🇸

Site reference no. 112520, Málaga, Spain

🇩🇪

Site reference no. 113475, Ulm, Germany

🇩🇪

Site reference no. 113456, Bochum, Germany

and more 7 locations

Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase

First Posted Date
2013-05-31
Last Posted Date
2019-09-23
Lead Sponsor
Sheffield Teaching Hospitals NHS Foundation Trust
Target Recruit Count
2
Registration Number
NCT01865695
Locations
🇬🇧

Department of Gastroenterology, Sheffield, South Yorkshire, United Kingdom

Evaluation of Safety and Tolerability of Creon Micro in Children Younger Than Four Years With Pancreatic Exocrine Insufficiency

Phase 3
Completed
Conditions
Interventions
First Posted Date
2012-12-11
Last Posted Date
2014-07-15
Lead Sponsor
Abbott Products
Target Recruit Count
40
Registration Number
NCT01747330
Locations
🇷🇺

Site Reference ID/Investigator# 80715, Orenburg, Russian Federation

🇷🇺

Site Reference ID/Investigator# 80716, Barnaul, Russian Federation

🇷🇺

Site Reference ID/Investigator# 80698, Novosibirsk, Russian Federation

and more 6 locations

Irritable Bowel Syndrome Evaluation and Treatment in Primary Care

First Posted Date
2012-07-16
Last Posted Date
2019-01-23
Lead Sponsor
American Academy of Family Physicians
Target Recruit Count
61
Registration Number
NCT01641341
Locations
🇺🇸

Baton Rouge Family Practice, Baton Rouge, Louisiana, United States

🇺🇸

American Academy of Family Physicians-National Research Network, Leawood, Kansas, United States

🇺🇸

Torrance Clinical Research, Lomita, California, United States

and more 6 locations

Special Investigation (All Cases) of LipaCreon in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis

First Posted Date
2011-09-02
Last Posted Date
2022-06-10
Lead Sponsor
Mylan Inc.
Target Recruit Count
24
Registration Number
NCT01427712
Locations
🇯🇵

Site reference ID/Investigator # 96698, Aichi, Japan

🇯🇵

Research facility ORG-000972, Ehime, Japan

🇯🇵

Site Reference ID/Investigator# 65530, Kagawa, Japan

and more 18 locations

Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2010-07-01
Last Posted Date
2010-07-01
Lead Sponsor
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Target Recruit Count
11
Registration Number
NCT01154608
Locations
🇫🇷

Centre de Recherche sur Volontaires, Bobigny, France

Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis

Phase 4
Completed
Conditions
First Posted Date
2009-08-12
Last Posted Date
2009-08-12
Lead Sponsor
Hospital Avicenne
Target Recruit Count
12
Registration Number
NCT00957151
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