Chorionic Gonadotropin (Human)

Generic Name: Chorionic Gonadotropin (Human)

Brand Names: Novarel, Pregnyl

Drug Type: Biotech

Chemical Formula: -

CAS Number: 9002-61-3

Unique Ingredient Identifier: 20ED16GHEB

Background: Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. Endogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows the corpus luteum to continuously secrete the hormone progesterone during the first trimester, which ...

Indication: For the treatment of prepubertal cryptorchidism (not due to anatomical obstruction), for the treatment of selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males and for the induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to ...

Associated Conditions: Idiopathic Hypogonadotropic Hypogonadism, Undescended Testis, Secondary Hypogonadotrophic hypogonadism

Associated Therapies: Ovulation induction therapy, Stimulation of spermatogenesis therapy

Clinical Trials

Ex vivo imaging reveals the spatiotemporal control of ovulation

Mice used in the study were maintained according to international welfare rules and approved by German authorities. Mouse strains CAG-TAG, Oct4–GFP, and C57BL/6J were used, with all mice kept under controlled conditions. Follicles were isolated and cultured, with live imaging of ovulation conducted using confocal and two-photon microscopy. Drug perturbations and follicle volume measurements were also part of the study. Single-cell suspensions and scRNA-seq were generated for in vivo and ex vivo datasets, with differential gene expression and GO enrichment analyses performed. Statistical methods included two-sided unpaired t-tests and chi-squared tests with Yates’s correction.

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