卡铂 (Paraplatin)

概览

Carboplatin is a alkylating agent used to treat advanced ovarian cancer.

作用机制

Carboplatin predominantly acts by attaching alkyl groups to the nucleotides, leading to the formation of monoadducts, and DNA fragmenting when repair enzymes attempt to correct the error. 2% of carboplatin's activity comes from DNA cross-linking from a base on one strand to a base on another, preventing DNA strands from separating for synthesis or transcription. Finally, carboplatin can induce a number of different mutations.

适应症

Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma. Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.

• Advanced Cervical Cancer
• Advanced Endometrial Cancer
• Advanced Esophageal Cancers
• Advanced Head and Neck Cancer
• Advanced Melanoma
• Advanced Non-Small Cell Lung Cancer (NSCLC)
• Advanced Ovarian Carcinoma
• Advanced Sarcoma
• Malignant Pleural Mesothelioma (MPM)
• Merkel Cell Carcinoma
• Metastatic Breast Cancer
• Refractory Hodgkin Lymphoma