Mometasone

Overview

Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions. It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and higher than many other corticosteroids as well. Mometasone furoate is formulated as a dry powder inhaler, nasal spray, and ointment for its different indications.

Background

Indication

Inhaled mometasone furoate is indicated for prophylaxis of asthma in patients ≥4 years. Applied topically as an ointment, mometasone furoate is indicated for symptomatic treatment of dermatitis and pruritis in patients ≥2 years. Mometasone furoate nasal spray is available both over-the-counter (OTC) and by prescription. The OTC nasal spray formulation of mometasone furoate is indicated for the treatment of upper respiratory allergic symptoms (e.g. rhinorrhea, sneezing) in patients ≥2 years of age. The prescription formulation is indicated for the treatment of chronic rhinosinusitis with nasal polyps in patients ≥18 year old and for the and prophylaxis of seasonal allergic rhinitis in patients ≥12 years old. It is also approved in combination with olopatadine for the symptomatic treatment of seasonal allergic rhinitis in patients ≥12 years.

Associated Conditions

Asthma
Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)
Dermatitis
Dermatitis, Eczematous caused by superficial Fungal skin infection
Moderate to Severe Plaque Psoriasis
Pruritus
Psoriasis
Psoriasis, Moderate to Severe
Seasonal Allergic Rhinitis
Seasonal Allergies
Skin Diseases, Eczematous
Skin Infections
Moderate, severe Seasonal Allergic Rhinitis
Ocular effects

Title	Posted	Study ID	Phase	Status	Sponsor
Single Dose Crossover Study of Patient Preference for Unscented Nasonex® Nasal Spray Versus Scented Flonase® Nasal Spray (Study P04207)	2009/01/06	NCT00817050	Phase 4	Completed	Organon and Co
Randomized Study to Compare the Bioavailability of Three Mometasone Furoate 0.1% Topical Lotions	2008/12/09	NCT00805155	N/A	Completed	Padagis LLC
A Study to Compare the Efficacy of QAV680 Against Placebo in Treating Seasonal Allergic Rhinitis in an Environmental Exposure Chamber	2008/11/04	NCT00784732	Phase 2	Completed	Novartis
Single Dose Crossover Study of Patient Preference for Unscented Nasonex® Nasal Spray Versus Scented Flonase® Nasal Spray (Study P04208)	2008/10/31	NCT00783458	Phase 4	Completed	Organon and Co
A Comparative Study of Mometasone Furoate Nasal Spray and Fluticasone Propionate Nasal Spray in Patients With Perennial Allergic Rhinitis (Study P04512)	2008/10/31	NCT00783224	Phase 3	Completed	Organon and Co
Onset of Effect of Mometasone Nasal Spray in Induced Allergic Rhinitis (Study P03431)	2008/10/31	NCT00783237	Phase 4	Completed	Organon and Co
A Study of Mometasone Furoate Nasal Spray in Perennial Allergic Rhinitis (Study P03748)(COMPLETED)	2008/10/24	NCT00779545	Phase 2	Completed	Organon and Co
Equivalency Study of Two Formulations of Mometasone Furoate Nasal Spray (Study P04419)	2008/10/24	NCT00779740	Phase 3	Completed	Organon and Co
Elocon vs Fluticasone in Localized Psoriasis (P03197)	2008/10/01	NCT00763529	Phase 4	Completed	Organon and Co
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)	2008/09/11	NCT00750750	Phase 2	Completed	Organon and Co

Title

Posted

Study ID

Phase

Status

Sponsor

Single Dose Crossover Study of Patient Preference for Unscented Nasonex® Nasal Spray Versus Scented Flonase® Nasal Spray (Study P04207)

2009/01/06

NCT00817050

Phase 4

Completed

Organon and Co