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CART-19

Generic Name
CART-19

Overview

No overview information available.

Indication

No indication information available.

Associated Conditions

No associated conditions information available.

Research Report

Published: May 24, 2025

Chimeric Antigen Receptor T-Cell Therapy Targeting CD19 (CART-19): A Comprehensive Report

1. Introduction to CART-19 Therapy

Defining CART-19: A Revolutionary Cellular Immunotherapy

Chimeric Antigen Receptor T-cell (CART) therapy targeting the CD19 protein (CART-19) represents a transformative class of adoptive cell transfer immunotherapy. This innovative approach involves the genetic modification of a patient's own T-lymphocytes (autologous T-cells) to recognize and eliminate cancer cells that express the CD19 antigen on their surface.[1] This therapy has emerged as a powerful and potentially curative option, particularly for patients with various B-cell hematological malignancies that are relapsed or refractory (r/r) to conventional treatments.[1] The personalized nature of CART-19 therapy, where T-cells are harvested from the patient, engineered ex vivo, expanded to therapeutic doses, and then re-infused, distinguishes it fundamentally from traditional pharmaceutical agents like small molecules or monoclonal antibodies.[1] The unprecedented efficacy observed in clinical trials has led to the approval of several CART-19 products by regulatory authorities such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).[3]

Continue reading the full research report

Clinical Trials

FDA Drug Approvals

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No FDA approvals found for this drug.

EMA Drug Approvals

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No EMA approvals found for this drug.

HSA Drug Approvals

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No HSA approvals found for this drug.

NMPA Drug Approvals

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No NMPA approvals found for this drug.

PPB Drug Approvals

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No PPB approvals found for this drug.

TGA Drug Approvals

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No TGA approvals found for this drug.

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