Thiopental

Overview

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)

Indication

For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.

Associated Conditions

Seizures

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in Erythrocytes	2024/07/03	NCT06485388	Not Applicable	Completed	Melike Cengiz
Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock	2017/04/07	NCT03104140	Phase 3	Completed	Cairo University
The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children	2015/07/01	NCT02486926	Not Applicable	Completed	Hallym University Medical Center
Comparative Effect of Theipoental and Propofol in IVF Outcome	2015/03/04	NCT02377778	Phase 4	Completed	Aristotle University Of Thessaloniki
The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone	2011/12/20	NCT01495949	Phase 4	Completed	Mahidol University
Onset Time of Thiopental Versus Propofol in the Elderly	2009/08/25	NCT00965107	Phase 4	Completed	Rigshospitalet, Denmark
The Effect of Intravenous Anesthetics on Fear Learning and Memory	2008/10/07	NCT00767767	Not Applicable	Completed	Weill Medical College of Cornell University
Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension	2008/02/25	NCT00622570	Phase 3	Terminated	Hospital Universitari Son Dureta
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence	2008/02/11	NCT00611767	Not Applicable	Completed	Yale University
Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes	2007/07/20	NCT00504894	Phase 4	Terminated	Weill Medical College of Cornell University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
Pentothal thiopental sodium 500 mg powder for injection vial	73505	Link Medical Products Pty Ltd T/A Link Pharmaceuticals	Medicine	A	3/21/2000
OMEGAPHARM THIOPENTAL SODIUM 470 mg thiopental sodium 470 mg powder for injection vial	209478	Omegapharm	Medicine	A	11/10/2015

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
PENTOTHAL READY TO MIX SYRINGE 250MG	hospira healthcare ulc	00372536	Powder For Solution - Intravenous	250 MG / SYR	12/31/1986
PENTOTHAL INJ 25MG/ML	hospira healthcare ulc	00695017	Powder For Solution - Intravenous	25 MG / ML	12/31/1988
PENTOTHAL SODIUM PWS 5GM	hospira healthcare ulc	00038415	Powder For Solution - Intravenous	5 G / BOTTLE	12/31/1975
PENTOTHAL SODIUM INJ 1GM STERILE	hospira healthcare ulc	00038407	Powder For Solution - Intravenous	1 G / VIAL	12/31/1951
PENTOTHAL INJ 500MG/SYR	hospira healthcare ulc	00038393	Powder For Solution - Intravenous	500 MG	12/31/1986

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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