硫喷妥钠

概览

Thiopental is a barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure.

作用机制

Thiopental binds at a distinct binding site associated with a Cl ionopore at the GABA receptor, increasing the duration of time for which the Cl ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

适应症

For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.

• Seizures