UCB-0022
- Generic Name
- UCB-0022
Five Promising Therapeutic Candidates in Parkinson's Disease Clinical Pipeline
• Ambroxol, a repurposed cough suppressant, shows potential as a disease-modifying therapy for Parkinson's by enhancing lysosomal function and clearing α-synuclein aggregates, with the GREAT trial currently evaluating its efficacy.
• Novel anti-inflammatory compounds targeting the NLRP3 inflammasome, including Inzomelid and NT-0796, are advancing through clinical trials as potential disease-modifying agents that could slow neurodegeneration in Parkinson's disease.
• Gene therapy approach AAV2-GDNF and innovative non-dopaminergic treatments like Solangepras and Glovadalen represent significant advances in the therapeutic pipeline, offering potential for durable neuroprotection and improved symptom management with fewer side effects.
UCB Showcases Promising Neurodegenerative Disease Research at AD/PD 2025
• UCB presented 8 scientific abstracts at AD/PD 2025, including subgroup analysis of bepranemab's TOGETHER trial for Alzheimer's disease, the first anti-tau therapy showing clinical efficacy.
• The company's Parkinson's disease research program features UCB7853, an anti-alpha-synuclein antibody, and glovadalen (UCB0022), an oral D1 receptor positive allosteric modulator designed for improved symptom control.
• Despite ORCHESTRA trial for minzasolmin not meeting clinical endpoints in early-stage Parkinson's disease, UCB continues advancing multiple therapeutic approaches targeting underlying disease mechanisms and symptom management.
UCB's Minzasolmin Fails Phase 2 ORCHESTRA Trial for Early Parkinson's Disease
• UCB's minzasolmin, an oral alpha-synuclein misfolding inhibitor, did not meet primary or secondary endpoints in the Phase 2 ORCHESTRA trial for early Parkinson's.
• The ORCHESTRA study enrolled over 450 patients to assess minzasolmin's efficacy, safety, tolerability, and pharmacokinetics over 12-18 months.
• UCB will terminate the extension phase of the minzasolmin program and shift focus to glovadalen (UCB0022) and UCB7583 for Parkinson's treatment.
• Analysis of disease biomarker data from the ORCHESTRA study is ongoing, with findings to be submitted for publication in a peer-reviewed journal.
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