Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of tw...
Abatacept is indicated in adult patients for the treatment of moderately-to-severely active rheumatoid arthritis and for the treatment of active psoriatic arthritis. In patients two years of age and older, abatacept is also indicated for the treatment of moderately-to-severely active juvenile idiopathic arthritis.
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Brigham and Women's Hospital, Boston, Massachusetts, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Boston Children's Hospital, Boston, Massachusetts, United States
St. Joseph's Healthcare, Hamilton, Ontario, Canada
Mayo Clinic, Rochester, Minnesota, United States
Hospital for Special Surgery, New York, New York, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Boston Children's Hospital, Boston, Massachusetts, United States
City Of Hope National Medical Center, Duarte, California, United States
Local Institution - 0083, Spokane, Washington, United States
Local Institution - 0024, Encino, California, United States
Local Institution - 0075, Brest, France
Benaroya Research Institute, Seattle, Washington, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Childrens Hospital of Orange County, Orange, California, United States
Stanford University, Palo Alto, California, United States
University of California San Francisco, San Francisco, California, United States
University of Mississippi Medical Center, Children's Center for Cancer and Blood Disorders, Jackson, Mississippi, United States
Columbia University Irving Medical Center, New York, New York, United States
Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, United States
University of Washington, Seattle, Washington, United States
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