Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Lehigh County Department of Drug & Alcohol Launches New Website, Rise Above Opioids
Lehigh County Department of Drug & Alcohol launches Rise Above Opioids, a website offering resources for opioid addiction, in partnership with Valley Youth House. The platform provides educational materials, support services, and a resource directory for prevention and recovery.
Austin, Travis County launch opioid resource hub to fight overdoses
Austin Public Health launched the Austin-Travis County Opioid Resource Hub to increase awareness and reduce drug overdoses. The hub provides resources like Naloxone distribution data, treatment centers, and educational materials. As of December 2024, 2,134 doses of Naloxone have been distributed. Dr. Desmar Walkes emphasizes the importance of familiarizing oneself with available resources to save lives.
Calls grow for Hochul to expand N.Y.-bought overdose reversal drugs in budget
Advocates urge Gov. Kathy Hochul to expand NY's overdose reversal medications, as traditional Narcan doses become less effective against fentanyl-laced drugs. The state Health Department plans to diversify its supply but not until current contracts expire. Legislation to mandate broader FDA-approved options failed in the Senate, prompting calls for immediate action in Hochul's upcoming State of the State address or budget proposal.
Public invited to Dec. 9 listening session on utilization of opioid settlement funds
Kenosha County Division of Behavioral Health Services hosts a community listening session on Dec. 9 to gather public input on how to use opioid settlement funds. The session aims to determine impactful investment strategies based on local needs, with Narcan training and behavioral health resources also available.
What an early discovery in a Syracuse lab could mean for late-stage breast cancer
Syracuse researchers discover potential new use for naloxone, a common anti-overdose drug, to alleviate suffering in breast cancer patients with bone metastasis.
Kenosha County Public Health now offering harm reduction vending machines at 3 locations
Kenosha County Public Health offers harm reduction vending machines at three locations, providing Narcan, fentanyl test strips, and other items free of charge. Machines are available 24/7 at the WIC office and Sharing Center, and from 8 a.m. to 5 p.m. at the Job Center. The HOPE Council also offers a similar machine.
TEVA Stock Down 10% in a Month: Should You Buy the Dip?
Teva Pharmaceutical Industries Limited's TEVA stock declined 10% despite strong Q3 results, driven by underwhelming guidance. The company's branded drugs Austedo and Ajovy are key growth drivers, with expected sales of $1.6 billion and $500 million in 2024, respectively. Teva's generics and biosimilars pipeline is robust, with several launches expected by 2027. The company resolved opioid litigation for $4.25 billion, and its stock valuation is attractive, making it a potential buying opportunity for long-term investors.
Drug Overdose Deaths Are Declining Due to Changes in the Drug Supply
US overdose deaths decline for 7 months due to weaker fentanyl, expanded treatment, and prevention efforts.
Macomb County drug overdoses drop, may be starting downward trend
Fatal drug overdoses in Macomb County dropped 25% in 2023, with nonfatal overdoses also declining, suggesting progress in combating the opioid crisis. Efforts include increased distribution of naloxone and fentanyl test strips, and expanded access to medication-assisted treatment.
Belltown residents report rampant drug activity despite new SODA law
Despite Seattle's new Stay Out of Drug Area (SODA) ordinance, Belltown residents report rampant drug activity, with frequent police presence and arrests, but unchecked fentanyl use. The SODA law, which bans certain drug offenders from designated zones, has not yet issued any bans, and critics argue it fails to address addiction's root causes.
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