Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Opioid vs. Opiate: Is There a Difference?
Opioids and opiates, though chemically distinct, share similarities in effects and uses, often leading to their interchangeable use. Opiates originate from the opium poppy, while opioids are lab-made. Both affect pain and pleasure, treat similar conditions, cause common side effects, and can be misused, leading to opioid use disorder and overdose risks.
One Pill Can Kill Initiative Launch Scheduled for Today
The U of A collaborates with Arkansas Attorney General Tim Griffin for the 'One Pill Can Kill' initiative, launching Oct. 29 to raise awareness about fentanyl and counterfeit pills. Events include a press conference, law enforcement training, and a student training session on opioid overdose response.
New Overdose Response Team Launched in Pickaway County to Combat Opioid Crisis
Pickaway County Public Health launches Pickaway Overdose Response Team (PORT) to combat opioid crisis, integrating Narcan distribution, QR code referral system, community engagement, and collaboration with first responders to reduce overdoses and connect individuals to treatment.
UT Tyler launching Naloxone Access initiative
UT Tyler launches Naloxone Access initiative, offering free Narcan to students, faculty, and staff during Fentanyl Poisoning Awareness Month. A music festival and artisan marketplace on Oct. 28 will distribute 100 doses of Narcan. Regular distribution sites open Oct. 29 on all campuses.
Earnings call: Aptar reports growth and robust Pharma segment in Q3
AptarGroup reported a 2% core sales growth and a 6% increase in adjusted EPS to $1.49 in Q3, driven by a 12% growth in its Pharma segment. The company acquired SipNose's technology assets to enhance intranasal delivery capabilities and expanded capacity in New York. Adjusted EBITDA margin reached 36%, and free cash flow doubled to $255 million. Aptar expects full-year adjusted EPS between $5.34 and $5.42, with a focus on productivity improvements and a $500 million share repurchase authorization.
Tarrant County gets first murder conviction tied to sale of fentanyl-laced pills
Tarrant County convicts Kaeden Farish, 19, to 19 years for fentanyl-related murder under new law. Farish sold fentanyl-laced pills to a 17-year-old who died. Fentanyl, 50x more potent than heroin, is the deadliest drug threat in the U.S., causing 66% of 2021's 107,622 overdose deaths. Rainbow fentanyl, brightly colored, aims to target young adults. Narcan, an opioid antagonist, temporarily reverses overdoses and is now over-the-counter.
Implant Might Prevent Opioid Overdose
Researchers developed an implant, Naloximeter, that detects opioid overdose and administers naloxone automatically, sending emergency alerts. The device, implanted in animals, successfully reversed overdoses, with potential for broader medical applications.
Broad Street Brief: City, CCP Launch Municipal Employment College
Mayor Parker launches City College for Municipal Employment; OTIS seeks public input on bike safety; City Council advances rent price-fixing ban; healthcare workers warn Sixers arena traffic could endanger patients; residents report police misuse of Narcan; judge dismisses school admissions policy lawsuit; Philadelphia biotech nonprofit secures $60M for AI-driven therapy repurposing; Philadelphia Film Festival highlights local talent; state House election outcome could impact Philadelphia's future.
Needle-free epinephrine was developed in San Diego
Epinephrine nasal spray Neffy, developed by ARS Pharmaceuticals, aims to reduce fear of needle injections for treating severe allergic reactions. FDA-approved for patients 66 lbs or heavier, it offers painless, instantaneous relief with potential side effects like throat irritation. ARS is working on lower doses for children and infants.
Drug Development Updates
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