Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Forget EpiPens. New treatment for severe allergic reactions skips the needle
ARS Pharmaceuticals introduces Neffy, a needle-free epinephrine nasal spray for treating severe allergic reactions, approved by the FDA. Aimed at reducing fear and hesitation associated with EpiPen injections, Neffy offers a simpler, quicker administration method, potentially improving treatment accessibility for millions.
Governor Abbott Launches “One Pill Kills” Statewide Campaign
Governor Greg Abbott launches Texas' 'One Pill Kills' campaign to combat the fentanyl crisis, emphasizing the drug's deadly impact and announcing new laws to classify fentanyl as poisoning and allow murder charges for distributors. Over 1,700 Texans died from fentanyl last year, with Texas law enforcement seizing enough fentanyl to kill every U.S. citizen.
New weapon in fentanyl fight on Long Island identifies drugs more safely
Suffolk County Police acquire five TruNarc devices to quickly identify over 500 narcotics through laser analysis, potentially saving lives of first responders and overdose victims by enabling rapid treatment. The devices, costing $150,000, were funded by the Suffolk County Police Foundation, aiming to prevent officer exposure to deadly fentanyl.
Boxes used to distribute overdose reversal drug Narcan
Jeff Card's family company, Mechanism Exchange & Repair, repurposes tin newspaper boxes to distribute free Naloxone, an opioid overdose reversal drug, across 35 states. This initiative, part of 'Save a Life Day,' aims to reduce stigma and increase access to life-saving medication amid the opioid crisis.
UW-Madison professors launch opioid overdose response center
UW Madison launches the Opioid Overdose Response Center (OORC) to combat the opioid epidemic in Wisconsin, offering harm reduction services and expanding education on opioid use. The center aims to sustain its initiatives beyond its initial funding period (Oct 2024-Sep 2025) and includes student involvement opportunities.
Vending machines that dispense free Narcan launch in Deep Ellum
Free Narcan vending machines launching in Deep Ellum, aiming to reduce opioid overdoses. By year's end, over 30 machines will be placed. Narcan, an opioid antagonist, temporarily reverses overdoses and is now available over-the-counter. Naloxone, the active ingredient in Narcan, works for 30-90 minutes, requiring immediate medical attention post-use. Fentanyl, a potent synthetic opioid, remains a significant threat, with 'rainbow fentanyl' targeting young adults.
St. Louis hospital aims to reduce drug overdoses in children
St. Louis Children’s Hospital launches pilot program offering 1,000 free lockboxes to families with children who have ingested medications, aiming to reduce drug overdoses. The boxes, 9.5x6x5 inches, are locked with a key and padlock, and are also provided to families in behavioral health crises. Missouri data shows a 500% increase in child poisoning deaths in 2022.
Is there a fentanyl vaccine? Clinical trials to start in Texas in 2025
Opioid overdoses in Texas surged, with Austin-Travis County EMS responding to 75 cases in days, including 50 in 24 hours. A fentanyl vaccine, under development by University of Houston researchers, aims to prevent addiction by blocking the drug from reaching the brain. Clinical trials are set to begin in 2025, though FDA approval and public availability could take 5-10 years. Free Narcan kits are available in Austin to combat overdoses.
Most Americans Unsure How to Help Someone in Opioid Overdose
Most Americans (77%) don't know how to help someone in opioid overdose. Naloxone and nalmefene, FDA-approved nasal sprays, can reverse opioid overdoses, but many are uncomfortable using them. Naloxone is available over the counter and from community programs. Administer if someone is unconscious, not breathing, and unresponsive.
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