Mesalazine

Generic Name
Mesalazine
Brand Names
Apriso, Asacol, Canasa, Delzicol, Lialda, Mezavant, Pentasa, Rowasa, Salofalk, Zaldyon
Drug Type
Small Molecule
Chemical Formula
C7H7NO3
CAS Number
89-57-6
Unique Ingredient Identifier
4Q81I59GXC
Background

An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease . Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stabil...

Indication

适用于溃疡性结肠炎和克罗恩病（Crohn病）。

Associated Conditions
Acute Ulcerative Colitis, Crohn's Disease Relapse, Crohn's Ileocolitis, Mild to Moderate Ulcerative Colitis, Proctitis, Proctitis, Ulcerative, Proctosigmoiditis, Ulcerative Colitis in Remission, Mild Ulcerative Colitis, Mild to moderate distal ulcerative colitis, Moderate Ulcerative colitis
Associated Therapies
-
Clinical Trials
Related News

Mercaptopurine Therapy in Ulcerative Colitis

First Posted Date
2016-09-22
Last Posted Date
2020-01-07
Lead Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Target Recruit Count
136
Registration Number
NCT02910245
Locations
🇳🇱

Meander MC, Amersfoort, Netherlands

🇳🇱

Amstelland Hospital, Amsterdam, Netherlands

🇳🇱

OLVG Oost, Amsterdam, Netherlands

and more 9 locations

Bio-enhanced Curcumin as an Add-On Treatment in Mild to Moderate Ulcerative Colitis

First Posted Date
2016-02-17
Last Posted Date
2016-02-23
Lead Sponsor
Asian Institute of Gastroenterology, India
Target Recruit Count
50
Registration Number
NCT02683733
Locations
🇮🇳

Asian Institutes of Gastroenterology, Hyderabad, Telangana, India

Combination Corticosteroids+5-aminosalicylic Acids Compared to Corticosteroids Alone (for Ulcerative Colitis).

Phase 3
Completed
Conditions
Ulcerative Colitis
Interventions
Drug: 5-ASA
Drug: Corticosteroids
First Posted Date
2016-01-28
Last Posted Date
2021-08-26
Lead Sponsor
Centre Hospitalier Universitaire de Saint Etienne
Target Recruit Count
160
Registration Number
NCT02665845
Locations
🇬🇷

Department of Gastroenterology Venizeleio General Hospital, Leoforos Knosou, Heraklion, Greece

🇷🇸

Zvezdara University Clinical Center, Gastroenterology Department, Belgrade, Serbia

🇫🇷

Chu Saint Etienne, Saint Etienne, France

and more 3 locations

Aminosalicylic Acid Withdrawal Study in Long Standing Inactive Ulcerative Colitis

First Posted Date
2015-09-01
Last Posted Date
2023-05-31
Lead Sponsor
Chinese University of Hong Kong
Target Recruit Count
177
Registration Number
NCT02537210
Locations
🇭🇰

Prince of Wales Hospital, Hong Kong, Hong Kong

Mesalamine 4 g Sachet for the Induction of Remission in Active, Mild to Moderate Ulcerative Colitis (UC)

Phase 3
Completed
Conditions
Ulcerative Colitis
Interventions
Drug: Placebo
Drug: Mesalamine
First Posted Date
2015-08-13
Last Posted Date
2021-03-15
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
228
Registration Number
NCT02522767
Locations
🇺🇸

Research Associates of South Florida, LLC, Miami, Florida, United States

🇺🇸

Biopharma Informatic Inc., Houston, Texas, United States

🇺🇸

Medical Research Center of Florida, Pembroke Pines, Florida, United States

and more 87 locations

Mesalamine 2 g Sachet for the Maintenance of Clinical and Endoscopic Remission in Ulcerative Colitis (UC)

Phase 3
Completed
Conditions
Ulcerative Colitis
Interventions
Drug: Placebo
Drug: Mesalamine
First Posted Date
2015-08-13
Last Posted Date
2021-11-08
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
276
Registration Number
NCT02522780
Locations
🇭🇺

Vasútegészségügyi Nonprofit Kiemelten Közhasznú Kft. Debreceni Egészségügyi Központja, Debrecen, Hungary

🇱🇻

Latvian Maritime Medicine Centre, Riga, Latvia

🇲🇽

Investigación Biomédica para el Desarrollo de Fármacos, S.A. de C.V., Zapopan, Mexico

and more 91 locations

QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®)

Completed
Conditions
Distal Ulcerative Colitis
Interventions
Drug: mesalazine
First Posted Date
2015-02-23
Last Posted Date
2018-07-05
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
117
Registration Number
NCT02368743
Locations
🇫🇷

Gastro-Entérologie et Hépatologie - CHU Brabois (there may be other sites in this country), Vandoeuvre-les-Nancy, France

Standardized Fecal Microbiota Transplantation for Inflammatory Bowel Disease

First Posted Date
2015-01-09
Last Posted Date
2015-01-09
Lead Sponsor
Yanling Wei
Target Recruit Count
40
Registration Number
NCT02335281
Locations
🇨🇳

Department of Gastroenterology, Research Institute of Surgery, Da ping Hospital, The Third Military Medical University, Chongqing, Chongqing, China

Phosphatidylcholine (LT-02) vs. Placebo vs. Mesalamine for Maintenance of Remission in Ulcerative Colitis (PROTECT-2)

Phase 3
Completed
Conditions
Ulcerative Colitis
Interventions
Drug: LT-02
Drug: Placebo
Drug: Mesalamine
First Posted Date
2014-10-31
Last Posted Date
2020-01-27
Lead Sponsor
Dr. Falk Pharma GmbH
Target Recruit Count
150
Registration Number
NCT02280629
Locations
🇩🇪

Agaplesion Markus-Krankenhaus, Frankfurt a.M., Germany

Induction and Maintenance of Remission With Pentasa as Ulcerative Colitis Treatment

Completed
Conditions
Ulcerative Colitis
Interventions
Drug: mesalazine
First Posted Date
2014-10-10
Last Posted Date
2022-05-20
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
150
Registration Number
NCT02261636
Locations
🇳🇱

Gelre Ziekenhuizen (there may be other sites in this country), Zutphen, Netherlands

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