Phenobarbital

Generic Name
Phenobarbital
Brand Names
Donnatal, Luminal, Phenobarb, Phenohytro, Sezaby
Drug Type
Small Molecule
Chemical Formula
C12H12N2O3
CAS Number
50-06-6
Unique Ingredient Identifier
YQE403BP4D
Background

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

Indication

For the treatment of all types of seizures except absence seizures.

Associated Conditions
Alcohol Withdrawal Syndrome, Anxiety, Febrile Convulsions, Hyperbilirubinemia, Insomnia, Menopausal Symptoms, Partial-Onset Seizures, Seizures, Generalized, Withdrawal Symptoms
Associated Therapies
Sedation

Lacosamide in Neonatal Status Epilepticus

Phase 3
Conditions
Interventions
First Posted Date
2022-03-22
Last Posted Date
2022-03-22
Lead Sponsor
Sherief Abd-Elsalam
Target Recruit Count
60
Registration Number
NCT05291455
Locations
🇪🇬

Kafrelsheikh University, Tanta, Kafrelsheikh, Egypt

Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit

First Posted Date
2019-11-07
Last Posted Date
2020-10-08
Lead Sponsor
OSF Healthcare System
Target Recruit Count
142
Registration Number
NCT04156464
Locations
🇺🇸

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Clonidine Versus Phenobarbital as Adjunctive Therapy for Neonatal Abstinence Syndrome

First Posted Date
2018-09-13
Last Posted Date
2021-11-10
Lead Sponsor
University of Tennessee Medical Center
Target Recruit Count
25
Registration Number
NCT03670160
Locations
🇺🇸

University of Tennessee Medical Center, Knoxville, Tennessee, United States

Childhood Convulsive Status Epilepticus Management In A Resource Limited Setting

Phase 3
Completed
Conditions
Interventions
First Posted Date
2018-08-28
Last Posted Date
2018-08-28
Lead Sponsor
University of Cape Town
Target Recruit Count
198
Registration Number
NCT03650270
Locations
🇿🇦

Red Cross War Memorial Children's Hospital, Cape Town, Western Cape, South Africa

Pharmacokinetics of Antiepileptics in Patients on CRRT

First Posted Date
2018-08-16
Last Posted Date
2021-10-05
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
18
Registration Number
NCT03632915
Locations
🇺🇸

University of Maryland Medical Center, Baltimore, Maryland, United States

Efficacy of Levetiracetam in Control of Neonatal Seizures Guided by an EEG

First Posted Date
2017-04-11
Last Posted Date
2017-04-11
Lead Sponsor
Cairo University
Target Recruit Count
40
Registration Number
NCT03107507
Locations
🇪🇬

Cairo University Children's Hospital (Abulreesh), Cairo Governorate, Egypt

Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus

First Posted Date
2017-01-20
Last Posted Date
2019-07-09
Lead Sponsor
Xuanwu Hospital, Beijing
Target Recruit Count
120
Registration Number
NCT03025906
Locations
🇨🇳

Xuanwu Hospital, Beijing, Beijing, China

🇨🇳

Xijing Hospital, Shanxi, Xi'an, China

🇨🇳

Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China

and more 3 locations

How to Treat Opiate Withdrawal in Neonates

First Posted Date
2016-06-23
Last Posted Date
2020-01-07
Lead Sponsor
University of Zurich
Target Recruit Count
120
Registration Number
NCT02810782
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