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Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects.
Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects.
Bimoclomol binds to HSF-1 and induces a prolonged binding of HSF-1 to the respective DNA elements. Since HSF-1 does not bind to DNA in the absence of stress, the bimoclomol-induced extension of HSF-1/DNA interaction may contribute to the chaperone co-induction of bimoclomol observed previously. These findings indicate that bimoclomol may be of value in targeting HSF-1 so as to induce up-regulation of protective Hsp-s in a non-stressful manner and for therapeutic benefit.
Investigated for use/treatment in neuropathy (diabetic) and wounds.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
