Venetoclax

The FDA granted fast track designation to HC-7366, a first-in-class GCN2 kinase modulator, for treating relapsed/refractory AML. HC-7366 is being studied in combination with azacitidine and venetoclax in AML or MDS AML, with a focus on safety, tolerability, and preliminary efficacy.

BCL-2 inhibitors like venetoclax target BCL-2 protein to trigger apoptosis in cancer cells, overcoming challenges in drug design due to protein-protein interactions. Combination therapies with agents like BTK inhibitors or anti-CD20 antibodies enhance outcomes in CLL, offering tailored treatment options. Understanding individual tumor biology and patient profiles is crucial for effective therapy.

Fixed-duration ibrutinib plus venetoclax showed significant survival benefits, durable responses, and acceptable safety in high-risk CLL/SLL patients, with 5-year OS rates of 90% or greater. The combination is approved for first-line treatment in 78 countries. High-risk genomic features like del(17p), TP53 mutations, and complex karyotype patients derived meaningful survival benefits. The 5-year PFS rates were improved in patients achieving undetectable MRD, with higher rates in those with undetectable MRD4. Safety profiles remained consistent with no new serious AEs reported.

References detail lymphoid neoplasm classification, genetic subtypes of diffuse large B cell lymphoma, molecular classification and treatment, and targeted therapies like polatuzumab vedotin and AKT inhibitors in lymphoma treatment.

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