Botulinum toxin type A

Generic Name: Botulinum toxin type A

Brand Names: Botox, Botox Cosmetic, Dysport, Jeuveau, Xeomin, Nuceiva

Drug Type: Biotech

Chemical Formula: -

CAS Number: 93384-43-1

Unique Ingredient Identifier: 0A6JH35GMQ

Background: In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperfections, muscle spasms, and other condit...

Indication: Botulinum toxin A is indicated for a variety of conditions, depending on the preparations. Cosmetically, it is used for the treatment of facial fine lines and wrinkles, specifically for upper facial rhytides, including forehead, lateral canthus, and glabellar lines.
...

Associated Conditions: Bladder pain, Blepharospasm, Cervical Dystonia, Chronic Migraine, Diabetic Neuropathies, Epicondylitis, Equinus deformity of foot, acquired, Facial Skin Wrinkles, Glabellar Frown Lines (GL), Lower Limb Spasticity, Myofascial Pain Syndrome, Neurogenic Detrusor Overactivity, Neurogenic Thoracic Outlet Syndrome, Overactive Bladder Syndrome (OABS), Post Stroke Pain, Postherpetic Neuralgia, Sialorrhea, Spasticity, Spinal Cord Injuries, Strabismus, TMJ Disorders, Trigeminal Neuralgia (TN), Upper Limb Spasticity, Urinary Incontinence (UI), Hypertonicity disorders of the 7th nerve, Moderate Glabellar Frown Lines (GL), Severe Glabellar Frown Lines (GL), Severe axillary hyperhidrosis

Associated Therapies: -

Clinical Trials

Efficacy of Nerve Block Versus Botox in Chronic Migraine Management

Not Applicable

Recruiting

Conditions: Chronic Migraine
Chronic Migraine, Headache

Interventions: Procedure: Nerve Block Injections
Drug: Botulinum Toxin A

First Posted Date: 2024-11-12

Last Posted Date: 2024-11-12

Lead Sponsor: Zagazig University

Target Recruit Count: 64

Registration Number: NCT06684249

Locations: 🇪🇬
Zagazig University, Faculty of Medicine, Zagazig, El-Sharkia, Egypt

Effects of Microtox on Facial Skin Quality, Fine Wrinkles, and Texture

Phase 1

Recruiting

Conditions: Skin Aging
Skin Wrinkling

Interventions: Drug: PrabotulinumtoxinA-Xvfs
Drug: saline solution (placebo)
Drug: IncobotulinumtoxinA

First Posted Date: 2024-09-20

Last Posted Date: 2024-09-20

Lead Sponsor: Kalpna Kay Durairaj, MD, FACS

Target Recruit Count: 20

Registration Number: NCT06604832

Locations: 🇺🇸
K. Kay Durairaj, MD, A Medical Corp., Pasadena, California, United States

Effect of Botulinum Toxin on Selective Motor Control and Pain in Diplegic Cerebral Palsy

Phase 4

Recruiting

Conditions: Cerebral Palsy Spastic Diplegia

Interventions: Other: Conventional Physical Therapy
Drug: OnabotulinumtoxinA

First Posted Date: 2024-09-04

Last Posted Date: 2024-10-15

Lead Sponsor: Gaziosmanpasa Research and Education Hospital

Target Recruit Count: 40

Registration Number: NCT06583343

Locations: 🇹🇷
Gaziosmanpasa Research and Education Hospital, Istanbul, Gaziosmanpaşa, Turkey

Evaluation of Efficacy of Botulinum Toxin A Plus Oral Tadalafil 5 mg in Diabetic Men With Erectile Dysfunction

Phase 2

Recruiting

Conditions: Erectile Dysfunction With Diabetes Mellitus

Interventions: Drug: Botulinum toxin A
Drug: Tadalafil 5mg

First Posted Date: 2024-09-04

Last Posted Date: 2024-12-03

Lead Sponsor: Aswan University Hospital

Target Recruit Count: 32

Registration Number: NCT06583590

Locations: 🇪🇬
Aswan University-Faculty of Medicine, Aswan, Aswan Governorate, Egypt

A Multicentre, Randomised, Single-blind, Controlled Protocol to Evaluate the Efficacy of Early Administration of Botulinum Toxin for Primary Midline Closure in Patients With Open Abdomen.

Phase 4

Not yet recruiting

Conditions: Botulinum Toxin Type A
Clinical Trial
Abdominal Wall
Open Abdomen

Interventions: Other: CONTROL
Drug: Botulinum Toxin A

First Posted Date: 2024-08-15

Last Posted Date: 2024-08-15

Lead Sponsor: Instituto de Investigación Hospital Universitario La Paz

Target Recruit Count: 50

Registration Number: NCT06556030

Pretreatment Botulinum Toxin in Head and Neck Cancer Surgery

Phase 2

Not yet recruiting

Conditions: Head Neck Cancer
Xerostomia Following Radiotherapy

Interventions: Drug: Placebo
Drug: OnabotulinumtoxinA

First Posted Date: 2024-07-31

Last Posted Date: 2024-07-31

Lead Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Target Recruit Count: 50

Registration Number: NCT06530524

Locations: 🇨🇦
McGill University, Montreal, Quebec, Canada

Thoracic Sympathetic Ganglion Block With Botulinum Toxin Type A

Not Applicable

Not yet recruiting

Conditions: Complex Regional Pain Syndromes

Interventions: Drug: Botulinum toxin A

First Posted Date: 2024-06-24

Last Posted Date: 2024-06-26

Lead Sponsor: Seoul National University

Target Recruit Count: 78

Registration Number: NCT06470581

Use of Botulinum Toxin A in Direct Eyebrow Lift Scar

Phase 2

Recruiting

Conditions: Skin Scarring
Eyebrow Ptosis

Interventions: Drug: Botulinum toxin type A

First Posted Date: 2024-06-18

Last Posted Date: 2024-06-18

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 40

Registration Number: NCT06465056

Locations: 🇧🇷
University of São Paulo (Clinical Hospital), São Paulo, Brazil
🇧🇷
Ophthalmology Dept. University of Sao Paulo General Hospital, Sao Paulo, Brazil