Botulinum toxin type A

Generic Name: Botulinum toxin type A

Brand Names: Botox, Botox Cosmetic, Dysport, Jeuveau, Xeomin, Nuceiva

Drug Type: Biotech

Chemical Formula: -

CAS Number: 93384-43-1

Unique Ingredient Identifier: 0A6JH35GMQ

Background: In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperfections, muscle spasms, and other condit...

Indication: Botulinum toxin A is indicated for a variety of conditions, depending on the preparations. Cosmetically, it is used for the treatment of facial fine lines and wrinkles, specifically for upper facial rhytides, including forehead, lateral canthus, and glabellar lines.
...

Associated Conditions: Bladder pain, Blepharospasm, Cervical Dystonia, Chronic Migraine, Diabetic Neuropathies, Epicondylitis, Equinus deformity of foot, acquired, Facial Skin Wrinkles, Glabellar Frown Lines (GL), Lower Limb Spasticity, Myofascial Pain Syndrome, Neurogenic Detrusor Overactivity, Neurogenic Thoracic Outlet Syndrome, Overactive Bladder Syndrome (OABS), Post Stroke Pain, Postherpetic Neuralgia, Sialorrhea, Spasticity, Spinal Cord Injuries, Strabismus, TMJ Disorders, Trigeminal Neuralgia (TN), Upper Limb Spasticity, Urinary Incontinence (UI), Hypertonicity disorders of the 7th nerve, Moderate Glabellar Frown Lines (GL), Severe Glabellar Frown Lines (GL), Severe axillary hyperhidrosis

Associated Therapies: -

Clinical Trials

Pilot Study of BOTOX for Migraine Headaches

Not Applicable

Terminated

Conditions: Migraine Headache

Interventions: Drug: Botulinum Toxin Type A

First Posted Date: 2009-02-25

Last Posted Date: 2018-09-26

Lead Sponsor: HealthPartners Institute

Target Recruit Count: 35

Registration Number: NCT00850421

Locations: 🇺🇸
Park Nicollet Health Services, Minneapolis, Minnesota, United States

Subcutaneous Botulinum Toxin for Cutaneous Allodynia - Enriched Responder Trial

Not Applicable

Terminated

Conditions: Pain

Interventions: Drug: Botulinum Toxin Type A
Drug: Saline

First Posted Date: 2009-01-15

Last Posted Date: 2017-08-15

Lead Sponsor: Stanford University

Target Recruit Count: 5

Registration Number: NCT00822926

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Botox for Cervical Dystonia Following EMG Mapping

Phase 4

Completed

Conditions: Cervical Dystonia

Interventions: Drug: Botulinum toxin A

First Posted Date: 2008-10-16

Last Posted Date: 2020-03-23

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 10

Registration Number: NCT00773253

Locations: 🇺🇸
University of California, San Francisco, San Francisco, California, United States

Intravesical Instillation of Botulinum Toxin Type A to Patients With Urge Urinary Incontinence

Phase 1

Conditions: Urge Urinary Incontinence

First Posted Date: 2008-10-10

Last Posted Date: 2009-08-04

Lead Sponsor: Glostrup University Hospital, Copenhagen

Target Recruit Count: 20

Registration Number: NCT00770406

Locations: 🇩🇰
Glostrup Hospital, Glostrup, Copenhagen, Denmark

Benefits of the Use of Botox in the Treatment of Empty Nose Syndrome Syndrome

Phase 1

Terminated

Conditions: Empty Nose Syndrome
Atrophic Rhinitis

Interventions: Drug: Botulinum Toxin Type A

First Posted Date: 2008-08-12

Last Posted Date: 2016-04-18

Lead Sponsor: Mayo Clinic

Target Recruit Count: 9

Registration Number: NCT00732680

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Subcutaneous Botulinum Toxin for Cutaneous Allodynia

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Placebo - Saline
Drug: Botulinum Toxin A

First Posted Date: 2008-07-30

Last Posted Date: 2017-10-25

Lead Sponsor: Stanford University

Target Recruit Count: 84

Registration Number: NCT00725322

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Botulinum Toxin Injection for Treatment of Vaginismus

Phase 3

Conditions: Vaginismus

Interventions: Drug: botulinum toxin
Drug: botulinum toxin A

First Posted Date: 2008-03-18

Last Posted Date: 2008-03-18

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 40

Registration Number: NCT00638066

Locations: 🇮🇷
Tehran University of Medical Sciences, Vali e Asr Reproductive Health Research Center, Tehran, Iran, Islamic Republic of

Efficacy Study of Botox to Treat Neuropathic Pain

Phase 4

Completed

Conditions: Postherpetic Neuralgia
Nerve Trauma

Interventions: Drug: botulinum toxin A

First Posted Date: 2007-09-10

Last Posted Date: 2021-05-05

Lead Sponsor: Hospital Ambroise Paré Paris

Target Recruit Count: 29

Registration Number: NCT00527202

Locations: 🇫🇷
Hôpital Ambroise Paré, AP-HP, Boulogne-billancourt, France

The Effect of Botox on Children With Cerebral Palsy

Completed

Conditions: Cerebral Palsy

First Posted Date: 2007-07-19

Last Posted Date: 2010-07-22

Lead Sponsor: Shriners Hospitals for Children

Target Recruit Count: 11

Registration Number: NCT00503620

Locations: 🇺🇸
Shriners Hospitals for Children, Philadelphia, Pennsylvania, United States

Dysport® Injection in the Treatment of Chronic Lateral Epicondylitis

Phase 3

Completed

Conditions: Tennis Elbow

Interventions: Drug: NaCl 0.9%
Drug: Botulinum Toxin A

First Posted Date: 2007-07-09

Last Posted Date: 2008-04-23

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 52

Registration Number: NCT00497913

Locations: 🇮🇷
Imam Khomeini Hospital, Tehran, Iran, Islamic Republic of

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