Simethicone
- Generic Name
- Simethicone
- Brand Names
- Phazyme
- Drug Type
- Small Molecule
- Chemical Formula
- C6H18O4Si3
- CAS Number
- 8050-81-5
- Unique Ingredient Identifier
- -
- Background
Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed.
Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
- Indication
Simethicone is indicated for the treatment of bloating, pressure, and cramps caused by gas. Simethicone is also used as part of bowel preparation for colonoscopies.
- Associated Conditions
- Abdominal Cramping, Abdominal Pain, Bloating, Colic, Diarrhea, Distension, Distention, Dyspepsia, Flatulence, Gastric Ulcer, Gastritis, Heartburn, Hiatus Hernia, Hyperacidity, Pain, Pancreatic Insufficiency, Peptic Esophagitis, Peptic Ulcer, Reflux Acid, Stomach ache, Gastrointestinal cramping, Gastrointestinal cramps caused by Gas, Gastrointestinal spasms, Stomach cramps
- Associated Therapies
- Antacid therapy, Bowel preparation therapy
Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders
- Conditions
- Interventions
- First Posted Date
- 2022-01-03
- Last Posted Date
- 2024-01-03
- Lead Sponsor
- Abbott
- Target Recruit Count
- 465
- Registration Number
- NCT05175131
- Locations
- 🇷🇺
Null Research Facilities, Moscow, Russian Federation
The Impact of Air Travel on Passenger Cognitive Functions
- Conditions
- Interventions
- Drug: Melatonin 5 mgDrug: CiticolineDrug: Cytochrome C6Drug: Sodium Chloride Oral ProductDrug: Potassium Chloride Oral ProductDrug: Sodium Citrate Oral ProductDrug: Dextrose Oral Tablet, ChewableDrug: Domperidone Oral ProductDrug: SimethiconeDrug: Acetylsalicylic acidDrug: Magnesium hydroxideDrug: Probiotic Formula
- First Posted Date
- 2021-03-17
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- Dinara Zhumanbayeva
- Target Recruit Count
- 50
- Registration Number
- NCT04802785
A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2020-09-10
- Lead Sponsor
- McNeil AB
- Target Recruit Count
- 48
- Registration Number
- NCT04186936
- Locations
- 🇷🇺
"Scientific and Research centre Eco-safety" Limited Liability Company, Saint-Petersburg, Russian Federation
Ingestion of Simethicone After Capsule Ingestion and Its Impact on Quality of Video Capsule Endoscopy- a Pilot Study
- First Posted Date
- 2017-05-25
- Last Posted Date
- 2018-06-26
- Lead Sponsor
- Albany Medical College
- Target Recruit Count
- 36
- Registration Number
- NCT03166605
- Locations
- 🇺🇸
Albany medical center, Albany, New York, United States
Does Simethicone Improve Operative Field in Gynecological Operations
- First Posted Date
- 2017-01-04
- Last Posted Date
- 2017-01-04
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT03009604
- Locations
- 🇪🇬
Assiut University, Assiut, Egypt
Gastric Preparation of Magnetic-controlled Capsule Endoscopy
- Conditions
- Interventions
- First Posted Date
- 2016-07-27
- Last Posted Date
- 2016-07-27
- Lead Sponsor
- Changhai Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT02846155
- Locations
- 🇨🇳
Changhai Hospital, Shanghai, China
Efficacy of Matricariae Chamomilla L., Melissa Officinalis L. and Tyndallized Lactobacillus Acidophilus (H122) for Infantile Colics
- First Posted Date
- 2016-03-15
- Last Posted Date
- 2016-07-29
- Lead Sponsor
- Federico II University
- Target Recruit Count
- 180
- Registration Number
- NCT02708238
Small Volume Simethicone Before Gastroscopy: Any Benefit?
- First Posted Date
- 2015-09-21
- Last Posted Date
- 2016-03-15
- Lead Sponsor
- Changi General Hospital
- Target Recruit Count
- 54
- Registration Number
- NCT02555228
- Locations
- 🇸🇬
Changi General Hospital, Singapore, Singapore
Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening
- Conditions
- Interventions
- First Posted Date
- 2015-08-14
- Last Posted Date
- 2020-02-12
- Lead Sponsor
- MercyOne Des Moines Medical Center
- Registration Number
- NCT02523911
- Locations
- 🇺🇸
UF Health Jacksonville, Jacksonville, Florida, United States
🇺🇸Iowa Endoscopy Center, Clive, Iowa, United States
Simethicone and N-acetylcysteine in Upper Endoscopy - Prospective Double-blinded Randomized Controlled Trial
- Conditions
- Interventions
- First Posted Date
- 2015-02-06
- Last Posted Date
- 2016-01-08
- Lead Sponsor
- Portuguese Oncology Institute, Coimbra
- Target Recruit Count
- 300
- Registration Number
- NCT02357303
- Locations
- 🇵🇹
Portuguese Oncology Institute - Coimbra, Coimbra, Portugal
Drug Development Updates
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