Simethicone
- Generic Name
- Simethicone
- Brand Names
- Phazyme
- Drug Type
- Small Molecule
- Chemical Formula
- C6H18O4Si3
- CAS Number
- 8050-81-5
- Unique Ingredient Identifier
- -
- Background
Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed.
Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
- Indication
Simethicone is indicated for the treatment of bloating, pressure, and cramps caused by gas. Simethicone is also used as part of bowel preparation for colonoscopies.
- Associated Conditions
- Abdominal Cramping, Abdominal Pain, Bloating, Colic, Diarrhea, Distension, Distention, Dyspepsia, Flatulence, Gastric Ulcer, Gastritis, Heartburn, Hiatus Hernia, Hyperacidity, Pain, Pancreatic Insufficiency, Peptic Esophagitis, Peptic Ulcer, Reflux Acid, Stomach ache, Gastrointestinal cramping, Gastrointestinal cramps caused by Gas, Gastrointestinal spasms, Stomach cramps
- Associated Therapies
- Antacid therapy, Bowel preparation therapy
Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation
- Conditions
- Interventions
- First Posted Date
- 2014-08-15
- Last Posted Date
- 2017-03-23
- Lead Sponsor
- Rocky Mountain MS Research Group, LLC
- Target Recruit Count
- 5
- Registration Number
- NCT02217982
- Locations
- 🇺🇸
Rocky Mountain MS Research Group, Salt Lake City, Utah, United States
Efficacy and Tolerability of Bisacodyl Sugar Coated Tablets, Simeticone Chewing Tablets and Their Combination in Constipation and Bloatedness
- First Posted Date
- 2014-08-08
- Last Posted Date
- 2014-08-08
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 30
- Registration Number
- NCT02211976
Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-06-11
- Last Posted Date
- 2015-12-04
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 100
- Registration Number
- NCT02161367
- Locations
- 🇨🇦
Juravinski Hospital, Hamilton, Ontario, Canada
🇨🇦St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy
- Conditions
- Interventions
- First Posted Date
- 2012-07-30
- Last Posted Date
- 2018-04-10
- Lead Sponsor
- Pontificia Universidad Catolica de Chile
- Target Recruit Count
- 230
- Registration Number
- NCT01653171
- Locations
- 🇨🇱
Hospital Clinico Pontificia Universidad Catolica de Chile, Santiago, Region Metropolitana, Chile
Effect of Simethicone on Eustachian Tube Dysfunction
- First Posted Date
- 2011-03-10
- Last Posted Date
- 2016-06-27
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 25
- Registration Number
- NCT01312038
- Locations
- 🇺🇸
Middle Ear Physiology Laboratory of Children's Hospital of PIttsburgh of UPMC, Pittsburgh, Pennsylvania, United States
The Effects of Moviprep With Simethicone on Colonic Bubbles
- Conditions
- Interventions
- First Posted Date
- 2010-09-27
- Last Posted Date
- 2019-07-15
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 140
- Registration Number
- NCT01209806
- Locations
- 🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
The Effectiveness of Simethicone In Improving Visibility During Colonoscopy
- First Posted Date
- 2008-02-14
- Last Posted Date
- 2013-02-22
- Lead Sponsor
- Ramathibodi Hospital
- Target Recruit Count
- 194
- Registration Number
- NCT00615303
- Locations
- 🇹🇭
Ramathibodi hospital, Bangkok, Thailand
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.