Gramicidin D
- Generic Name
- Gramicidin D
- Brand Names
- Sofracort, Soframycin, Triple Antibiotic, Viaderm Kc
- Drug Type
- Small Molecule
- Chemical Formula
- C96H135N19O16
- CAS Number
- 1405-97-6
- Unique Ingredient Identifier
- 5IE62321P4
Overview
Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. Active against most Gram-positive bacteria and some Gram-negative organisms, Gramicidin D is used primarily as a topical antibiotic and is also found in Polysporin ophthalmic solution.
Background
Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. Active against most Gram-positive bacteria and some Gram-negative organisms, Gramicidin D is used primarily as a topical antibiotic and is also found in Polysporin ophthalmic solution.
Indication
For treatment of skin lesions, surface wounds and eye infections.
Associated Conditions
- Allergic Conjunctivitis (AC)
- Allergic Skin Reaction
- Blepharoconjunctivitis
- Conjunctivitis
- Conjunctivitis infective
- Episcleritis
- External ear inflammation
- Eye and eyelid infections
- Inflammatory Skin Disease
- Iridocyclitis
- Keratitis
- Ocular Inflammation
- Otitis Externa
- Rosacea conjunctivitis
- Scleritis
- Seborrhoea of the External Ear
- Stye
- Ulcerative keratitis
- Bacterial blepharitis
- Infected eczema of the Eyelid
- Superficial ocular infections
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|---|---|---|---|---|
OPHTHALMIC | 0.025 mg in 1 mL | 2011/11/07 | 55045-1194 | ||
OPHTHALMIC | 0.025 mg in 1 mL | 2011/05/04 | 54868-6253 | ||
OPHTHALMIC | 0.025 mg in 1 mL | 2022/08/02 | 50090-0247 | ||
OPHTHALMIC | 0.025 mg in 1 mL | 2022/08/02 | 24208-790 | ||
OPHTHALMIC | 0.025 mg in 1 mL | 2007/02/22 | 21695-528 |
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
HSA Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
|---|
No HSA products found
No HSA products found for this drug
NMPA Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|
No NMPA products found
No NMPA products found for this drug
PPB Approved Products
Product Name | Registration Code | Company | Category | Sale Type | Reg. Date |
|---|---|---|---|---|---|
HK-18137 | wilcome pharmaceutical co ltd | Part 1, Schedule 1 & Schedule 3 Poison & Antibiotic | POM | 1982/08/31 |
TGA Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|---|---|---|---|---|
157804 | Active | 2008/12/12 | gramicidin | ||
19201 | Active | 1991/09/30 | gramicidin | ||
43840 | Pharmaco Australia Ltd | Active | 1993/04/01 | gramicidin | |
56477 | Active | 1996/08/07 | gramicidin | ||
13539 | Pharmaco Australia Ltd | Active | 1991/08/30 | gramicidin | |
19200 | Active | 1991/09/30 | gramicidin | ||
19197 | Active | 1991/09/30 | gramicidin | ||
56460 | Active | 1996/08/07 | gramicidin |